ArticleJournal of hypertension2013
Prolonged treatment with angiotensin 1-7 improves endothelial function in diet-induced obesity.
Article in Journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases.Cell cycle (Georgetown, Tex.) · 2023Review
- Vascular effects of disrupting endothelial mTORC1 signaling in obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling in Endothelial and Smooth Muscle Cells Is Required for Vascular Function.Hypertension (Dallas, Tex. : 1979) · 2021Article
- ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19.Clinical science (London, England : 1979) · 2020Review
- Activation of hypothalamic AgRP and POMC neurons evokes disparate sympathetic and cardiovascular responses.American journal of physiology. Heart and circulatory physiology · 2020Article
- Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes.American journal of physiology. Endocrinology and metabolism · 2020Review
- Stimulation of the ACE2/Ang-(1-7)/Mas axis in hypertensive pregnant rats attenuates cardiovascular dysfunction in adult male offspring.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Angiotensin-(1-7): Translational Avenues in Cardiovascular Control.American journal of hypertension · 2019Review
- Angiotensin-(1-7) contributes to insulin-sensitizing effects of angiotensin-converting enzyme inhibition in obese mice.American journal of physiology. Endocrinology and metabolism · 2018Article
- Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2018Article
- The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7).Physiological reviews · 2018Review
- Vascular endothelial dysfunction and pharmacological treatment.World journal of cardiology · 2015Review
- International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].Pharmacological reviews · 2015Review
- Effects of apelin on the cardiovascular system.Heart failure reviews · 2015Review
- Obesity-associated hypertension: recent progress in deciphering the pathogenesis.Hypertension (Dallas, Tex. : 1979) · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe renin-angiotensin system peptides are critically involved in the regulation of endothelial function with important pathological implications. Angiotensin (Ang) 1-7 has many beneficial effects in the vasculature that modulate the cardiovascular risk. Here, we tested the hypothesis that Ang 1-7 has a protective role against the endothelial defects associated with diet-induced obesity (DIO) in mice.
methodsAng 1-7 (with or without Ang II) was delivered subcutaneously for 4 weeks using osmotic minipumps. Vascular studies were performed using aortic rings. Arterial pressure and heart rate were measured in separate cohorts of mice by telemetry.
resultsFirst, we examined whether chronic administration of Ang 1-7 improves the vascular dysfunctions caused by Ang II. Subcutaneous coinfusion of Ang 1-7 significantly attenuates Ang II-induced endothelial dysfunctions. In addition, DIO mice have significant impairment in the endothelium-dependent relaxation. The contractile responses induced by various stimuli, including serotonin and endothelin-1, were differentially altered in DIO mice. Notably, DIO mice treated with Ang 1-7 for 4 weeks displayed significant improvement in the endothelial function as indicated by the increased acetylcholine-induced relaxation. Consistent with this, chronic treatment with Ang 1-7 reversed the increased aortic expression of NAD(P)H oxidase subunits (p22(phox) and p47(phox)) and plasma TBARS associated with DIO mice. In contrast, treatment with Ang 1-7 did not normalize the altered contractions associated with DIO mice.
conclusionOur data demonstrate a novel role for Ang 1-7 in improving obesity-associated endothelial dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.