ArticleAging2013
Peroxisomal catalase deficiency modulates yeast lifespan depending on growth conditions.
Article in Aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Exogenous glucosylglycerol and proline extend the chronological lifespan of Rhodosporidium toruloides.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Article
- Glucosylglycerol Extends Chronological Lifespan of the Budding Yeast via an Increased Osmolarity Response.Indian journal of microbiology · 2023Article
- Post-translational modifications of proteins associated with yeast peroxisome membrane: An essential mode of regulatory mechanism.Genes to cells : devoted to molecular & cellular mechanisms · 2021Review
- Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity.Current genetics · 2017Review
- Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease.Oxidative medicine and cellular longevity · 2017Review
- Article
- Article
- Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast.Aging · 2016Article
- Effect of paraquat-induced oxidative stress on gene expression and aging of the filamentous ascomyceteMicrobial cell (Graz, Austria) · 2014Article
- Cell-autonomous mechanisms of chronological aging in the yeastMicrobial cell (Graz, Austria) · 2014Review
- At neutral pH the chronological lifespan ofMicrobial cell (Graz, Austria) · 2014Article
- The significance of peroxisome function in chronological aging of Saccharomyces cerevisiae.Aging cell · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the role of peroxisomal catalase in chronological aging of the yeastHansenula polymorpha in relation to various growth substrates. Catalase-deficient (cat) cells showed a similar chronological life span (CLS) relative to the wild-type control upon growth on carbon and nitrogen sources that are not oxidized by peroxisomal enzymes. However, when media contained methylamine, which is oxidized by peroxisomal amine oxidase, the CLS of cat cells was significantly reduced. Conversely, the CLS of cat cells was enhanced relative to the wild-type control, when cells were grown on methanol, which is oxidized by peroxisomal alcohol oxidase. At these conditions strongly enhanced ROS levels were observed during the exponential growth phase of cat cells. This was paralleled by activation of the transcription factor Yap1, as well as an increase in the levels of the antioxidant enzymes cytochrome c peroxidase and superoxide dismutase. Upon deletion of the genes encoding Yap1 or cytochrome c peroxidase, the CLS extension of cat cells on methanol was abolished. These findings reveal for the first time an important role of enhanced cytochrome c peroxidase levels in yeast CLS extension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.