ArticlePloS one2013
Signature of balancing selection at the MC1R gene in Kunming dog populations.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Characterization of age-related changes in the gut microbiome and metabolome of Kunming dogs and their associations with police performance.Microbiome · 2026Article
- Heterozygosity-Rich Regions in Canine Genome: Can They Serve as Indicators of Balancing Selection?Animals : an open access journal from MDPI · 2025Article
- Effects of fecal microbial transplantation on police performance and transportation stress in Kunming police dogs.Applied microbiology and biotechnology · 2024Article
- Transcriptomic and intervention evidence reveals domestic dogs as a promising model for anti-inflammatory investigation.Aging cell · 2024Article
- White and other fur colourations and hybridization in golden jackals (Canis aureus) in the Carpathian basin.Scientific reports · 2023Article
- Genomic selection analysis of morphological and adaptation traits in Chinese indigenous dog breeds.Frontiers in veterinary science · 2023Article
- Behavioral evidence for the origin of Chinese Kunming dog.Current zoology · 2021Article
- Article
- Genetic Variation in Coat Colour GenesFrontiers in genetics · 2018Article
- Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene.Asian-Australasian journal of animal sciences · 2017Article
- Renal Artery Vasodilation May Be An Indicator of Successful Sympathetic Nerve Damage During Renal Denervation Procedure.Scientific reports · 2016Article
- Balancing selection on CDH2 may be related to the behavioral features of the Belgian Malinois.PloS one · 2014Article
- Nucleotide diversity of Maize ZmBT1 gene and association with starch physicochemical properties.PloS one · 2014Article
- Evolution and Cell Physiology. 1. Cell signaling is all of biology.American journal of physiology. Cell physiology · 2013Review
- Cross-amplification and validation of SNPs conserved over 44 million years between seals and dogs.PloS one · 2013Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coat color in dog breeds is an excellent character for revealing the power of artificial selection, as it is extremely diverse and likely the result of recent domestication. Coat color is generated by melanocytes, which synthesize pheomelanin (a red or yellow pigment) or eumelanin (a black or brown pigment) through the pigment type-switching pathway, and is regulated by three genes in dogs: MC1R (melanocortin receptor 1), CBD103 (β-defensin 103), and ASIP (agouti-signaling protein precursor). The genotypes of these three gene loci in dog breeds are associated with coat color pattern. Here, we resequenced these three gene loci in two Kunming dog populations and analyzed these sequences using population genetic approaches to identify evolutionary patterns that have occurred at these loci during the recent domestication and breeding of the Kunming dog. The analysis showed that MC1R undergoes balancing selection in both Kunming dog populations, and that the Fst value for MC1R indicates significant genetic differentiation across the two populations. In contrast, similar results were not observed for CBD103 or ASIP. These results suggest that high heterozygosity and allelic differences at the MC1R locus may explain both the mixed color coat, of yellow and black, and the difference in coat colors in both Kunming dog populations.
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