ArticleComputational and mathematical methods in medicine2013
Altered knee joint mechanics in simple compression associated with early cartilage degeneration.
Article in Computational and mathematical methods in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Longitudinal analysis of tibiofemoral cartilage contact area and position in ACL reconstructed patients.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Trial
- Biomechanical effects of medial osteoarthritis progression and UKA on knee lateral compartment using fibril-reinforced biphasic material in finite element study.Scientific reports · 2025Article
- Implication of region-dependent material properties of articular cartilage in the contact mechanics of porcine knee joint.BMC musculoskeletal disorders · 2025Article
- Computational study of extrinsic factors affecting ACL strain during single-leg jump landing.BMC musculoskeletal disorders · 2024Article
- A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait.PLoS computational biology · 2022Article
- Synthetic PVA Osteochondral Implants for the Knee Joint: Mechanical Characteristics During Simulated Gait.The American journal of sports medicine · 2021Article
- Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents.Scientific reports · 2021Article
- Prediction of local fixed charge density loss in cartilage following ACL injury and reconstruction: A computational proof-of-concept study with MRI follow-up.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Experimental Study on the Mechanical Properties of Porcine Cartilage with Microdefect under Rolling Load.Journal of healthcare engineering · 2017Article
- Assessment of Knee Cartilage Stress Distribution and Deformation Using Motion Capture System and Wearable Sensors for Force Ratio Detection.Computational and mathematical methods in medicine · 2015Article
- Finite element prediction of transchondral stress and strain in the human hip.Journal of biomechanical engineering · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The progression of osteoarthritis can be accompanied by depth-dependent changes in the properties of articular cartilage. The objective of the present study was to determine the subsequent alteration in the fluid pressurization in the human knee using a three-dimensional computer model. Only a small compression in the femur-tibia direction was applied to avoid numerical difficulties. The material model for articular cartilages and menisci included fluid, fibrillar and nonfibrillar matrices as distinct constituents. The knee model consisted of distal femur, femoral cartilage, menisci, tibial cartilage, and proximal tibia. Cartilage degeneration was modeled in the high load-bearing region of the medial condyle of the femur with reduced fibrillar and nonfibrillar elastic properties and increased hydraulic permeability. Three case studies were implemented to simulate (1) the onset of cartilage degeneration from the superficial zone, (2) the progression of cartilage degeneration to the middle zone, and (3) the progression of cartilage degeneration to the deep zone. As compared with a normal knee of the same compression, reduced fluid pressurization was observed in the degenerated knee. Furthermore, faster reduction in fluid pressure was observed with the onset of cartilage degeneration in the superficial zone and progression to the middle zone, as compared to progression to the deep zone. On the other hand, cartilage degeneration in any zone would reduce the fluid pressure in all three zones. The shear strains at the cartilage-bone interface were increased when cartilage degeneration was eventually advanced to the deep zone. The present study revealed, at the joint level, altered fluid pressurization and strains with the depth-wise cartilage degeneration. The results also indicated redistribution of stresses within the tissue and relocation of the loading between the tissue matrix and fluid pressure. These results may only be qualitatively interesting due to the small compression considered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.