ArticleClinical & developmental immunology2013
Detection and analysis of autoantigens targeted by autoantibodies in immunorelated pancytopenia.
Article in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Role of T cell-induced autoimmune response in the pathogenesis of glaucoma.International ophthalmology · 2024Review
- Deletion in 1p36.33-p36.32 is associated with pancytopenia: a case report.BMC medical genomics · 2023Article
- Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immune‑related pancytopenia.Molecular medicine reports · 2020Article
- Effects of Epstein-Barr Virus Infection on CD19+ B Lymphocytes in Patients with Immunorelated Pancytopenia.Journal of immunology research · 2020Article
- Th9 Cells in Peripheral Blood Increased in Patients with Immune-Related Pancytopenia.Journal of immunology research · 2020Article
- Abnormal numbers of CD4+ T lymphocytes and abnormal expression of CD4+ T lymphocyte‑secreted cytokines in patients with immune‑related haemocytopenia.Molecular medicine reports · 2019Article
- Aplastic Anemia in China.Journal of translational internal medicine · 2018Article
- Screening novel autoantigens targeted by serum IgG autoantibodies in immunorelated pancytopenia by SEREX.International journal of hematology · 2017Article
- [Quantities and function of NK cells in patients with positive BMMNC-Coombs test and cytopenia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2016Article
- Distinguishing immunorelated haemocytopenia from idiopathic cytopenia of undetermined significance (ICUS): a bone marrow abnormality mediated by autoantibodies.Clinical and experimental immunology · 2014Article
- Erythroblastic islands in the bone marrow of patients with immune-related pancytopenia.PloS one · 2014Article
- Increased frequency of bone marrow T follicular helper cells in patients with immune-related pancytopenia.Clinical & developmental immunology · 2013Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we described a group of patients with hemocytopenia who did not conform to diagnostic criteria of known hematological and nonhematological diseases. Most patients responded well to adrenocortical hormone and/or high-dose intravenous immunoglobulin treatment, indicating that cytopenia might be mediated by autoantibodies. Autoantibodies were detected on the membrane of various bone marrow (BM) hemopoietic cells by bone marrow mononuclear-cell-Coombs test or flow cytometric analysis. Thus, the hemocytopenia was termed "Immunorelated Pancytopenia" (IRP) to distinguish it from other pancytopenias. Autoantigens in IRP were investigated by membrane protein extraction from BM hemopoietic cells and BM supernatant from IRP patients. Autoantibody IgG was detected in the BM supernatant of 75% of patients (15/20), which was significantly higher than that in aplastic anemia, myelodysplastic syndrome, or autoimmune hemolytic anemia patients (0%) and normal healthy controls (0%) (P < 0.01). Autoantigens had approximate molecular weights of 25, 30, 47.5, 60, 65, 70, and 80 kDa, some of which were further identified by mass fingerprinting. This study identified that a G-protein-coupled receptor 156 variant and chain P, a crystal structure of the cytoplasmic domain of human erythrocyte band-3 protein, were autoantigens in IRP. Further studies are needed to confirm the antigenicity of these autoantigens.
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