ArticleAnnals of biomedical engineering2013
Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Rapid and Efficient Aerosol Delivery During 60 L/min High Flow Nasal Cannula Therapy-In Vitro Development of a Novel Dry Powder Delivery Platform.AAPS PharmSciTech · 2026Article
- Development of an Infant Air-Jet Dry Powder Aerosol Delivery System (iDP-ADS) Including a New Multifunctional Bifurcating Two-Prong Nasal Interface.Pharmaceutical research · 2025Article
- Development of CPAP Overlay Interfaces for Efficient Administration of Aerosol Surfactant Therapy to Preterm Infants.AAPS PharmSciTech · 2025Article
- Development of an effective two-equation turbulence modeling approach for simulating aerosol deposition across a range of turbulence levels.Journal of aerosol science · 2024Article
- In Vitro Evaluation of Nebulized Pharmaceutical Aerosol Delivery to the Lungs Using a New Heated Dryer System (HDS).AAPS PharmSciTech · 2022Article
- Article
- Aerosol delivery through high-flow nasal therapy: Technical issues and clinical benefits.Frontiers in medicine · 2022Review
- High-Efficiency Dry Powder Aerosol Delivery to Children: Review and Application of New Technologies.Journal of aerosol science · 2021Article
- Initial Development of an Air-Jet Dry Powder Inhaler for Rapid Delivery of Pharmaceutical Aerosols to Infants.Journal of aerosol medicine and pulmonary drug delivery · 2021Article
- CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery.Pharmaceutical research · 2020Article
- Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs.Journal of aerosol medicine and pulmonary drug delivery · 2019Review
- Development of a High-Flow Nasal Cannula and Pharmaceutical Aerosol Combination Device.Journal of aerosol medicine and pulmonary drug delivery · 2019Article
- High-Efficiency Nose-to-Lung Aerosol Delivery in an Infant: Development of a Validated Computational Fluid Dynamics Method.Journal of aerosol medicine and pulmonary drug delivery · 2019Article
- Use of computational fluid dynamics deposition modeling in respiratory drug delivery.Expert opinion on drug delivery · 2019Review
- Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume.Pharmaceutical research · 2018Article
- Development of an Inline Dry Powder Inhaler That Requires Low Air Volume.Journal of aerosol medicine and pulmonary drug delivery · 2018Article
- Application of an inline dry powder inhaler to deliver high dose pharmaceutical aerosols during low flow nasal cannula therapy.International journal of pharmaceutics · 2018Article
- Inhalation Techniques Used in Patients with Respiratory Failure Treated with Noninvasive Mechanical Ventilation.Canadian respiratory journal · 2018Review
- Fluid flow and particle transport in mechanically ventilated airways. Part II: particle transport.Medical & biological engineering & computing · 2016Article
- Generating Charged Pharmaceutical Aerosols Intended to Improve Targeted Drug Delivery in Ventilated Infants.Journal of aerosol science · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Aerosol delivery efficiency during noninvasive ventilation (NIV) is known to be low (~10%) and is associated with poor outcomes of aerosol therapy. The objective of this study was to demonstrate the benefit of redesigning ventilation circuit components using a streamlining approach to improve aerosol delivery during nasal high flow therapy in adults with a conventional-sized aerosol from a mesh nebulizer. The ventilation circuit consisted of a humidifier, mesh nebulizer, mixing T-connector (with 90° angle), 10 mm tubing, and nasal cannula interface. In vitro experiments and computational fluid dynamics analyses were used to evaluate depositional losses in a system of existing components and a newly proposed streamlined T-connector and cannula at flow rates of 30 and 45 LPM. Streamlined designs reduced deposition in the T-connector by a factor of 4. In the nasal cannula, the streamlined designs reduced depositional losses by factors of 1.25-2.0. With the streamlined designs, the highest emitted dose achieved was >40% for a conventional-sized aerosol at 30 LPM. Streamlined geometries offer an effective method to significantly improve the delivery of aerosols through components of NIV systems. This increase in delivery efficiency is important for new inhaled medications with narrow therapeutic windows, increased costs, or long delivery times.
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Registered trials
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