ArticleDiabetologia2013
Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding.
Article in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
261 citing papers in PubMed, 2 syntheses or guidelines pooled it, 414 citations in OpenAlex.
- Effects of high-fat diets on fetal growth in rodents: a systematic review.Reproductive biology and endocrinology : RB&E · 2019Pooled it
- Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017Pooled it
- Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs.The international journal of neuropsychopharmacology · 2026Article
- Dysregulated glucagon signaling contributes to hypoglycemia after vertical sleeve gastrectomy in mice.Molecular metabolism · 2026Article
- Repairing Atp10D in C57Bl/6J mice restores protein expression but does not mitigate metabolic stress from high fat diet.Scientific reports · 2026Article
- Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolism.bioRxiv : the preprint server for biology · 2026Article
- Chronic High-Fat Diet Does Not Alter Overall Cancer Incidence in Trp53R270H/+ Mice.Cancer research communications · 2026Article
- Ligature-induced periodontitis exacerbates high-carbohydrate/high-fat diet-induced fatty liver in mice under non-diabetic conditions.BMC oral health · 2026Article
- Article
- Sex-Specific Role of NPVF Signalling in Homeostatic Control.Biomolecules · 2026Article
- Development of Insulin and Leptin Resistance in the Mouse Brainstem with Age.Molecular neurobiology · 2026Article
- Metabolic dysfunction and GZMKFrontiers in immunology · 2026Review
- Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.Handbook of experimental pharmacology · 2026Review
- Acupoint catgut embedding exerts node-dependent effects on leptin resistance-related signaling and the ghrelin-GOAT pathway in obese mice.Frontiers in nutrition · 2026Article
- Glial Plasticity and Metabolic Stability After Knockdown of Astrocytic Cx43 in the Dorsal Vagal Complex.Cells · 2025Article
- High-Fat Diet Alters Behavior and Hippocampal Gene Expression.International journal of molecular sciences · 2025Article
- Haploinsufficiency of the Tyrosine Hydroxylase Gene in the Inbred C57BL/6J Strain Alters Behavior, Immunity, and Oxidative Stress, Especially After Acute Stress.International journal of molecular sciences · 2025Article
- Article
- Neuroendocrinology and the Genetics of Obesity.Endocrinology · 2025Review
- Navigating the Strengths and Constraints of Mouse Models in Obesity Research.Endocrinology · 2025Review
201 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisMetabolic disorders are commonly investigated using knockout and transgenic mouse models. A variety of mouse strains have been used for this purpose. However, mouse strains can differ in their inherent propensities to develop metabolic disease, which may affect the experimental outcomes of metabolic studies. We have investigated strain-dependent differences in the susceptibility to diet-induced obesity and insulin resistance in five commonly used inbred mouse strains (C57BL/6J, 129X1/SvJ, BALB/c, DBA/2 and FVB/N).
methodsMice were fed either a low-fat or a high-fat diet (HFD) for 8 weeks. Whole-body energy expenditure and body composition were then determined. Tissues were used to measure markers of mitochondrial metabolism, inflammation, oxidative stress and lipid accumulation.
resultsBL6, 129X1, DBA/2 and FVB/N mice were all susceptible to varying degrees to HFD-induced obesity, glucose intolerance and insulin resistance, but BALB/c mice exhibited some protection from these detrimental effects. This protection could not be explained by differences in mitochondrial metabolism or oxidative stress in liver or muscle, or inflammation in adipose tissue. Interestingly, in contrast with the other strains, BALB/c mice did not accumulate excess lipid (triacylglycerols and diacylglycerols) in the liver; this is potentially related to lower fatty acid uptake rather than differences in lipogenesis or lipid oxidation. CONCLUSIONS/
interpretationCollectively, our findings indicate that most mouse strains develop metabolic defects on an HFD. However, there are inherent differences between strains, and thus the genetic background needs to be considered carefully in metabolic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.