ReviewCurrent pain and headache reports2013
Mechanism of action of indomethacin in indomethacin-responsive headaches.
Review in Current pain and headache reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- The potential role of indomethacin in COVID-19 management: A systematic review of therapeutic and mechanistic evidence.New microbes and new infections · 2026Review
- Assessing Blood-brain Barrier Function in the Context of Pain Management.Central nervous system agents in medicinal chemistry · 2024Review
- Effect of felodipine on indomethacin-induced gastric ulcers in rats.Experimental animals · 2023Article
- A collection of cannabinoid-related negative findings from autaptic hippocampal neurons.Scientific reports · 2023Article
- Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions.Nanoscale advances · 2023Review
- Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option.Frontiers in neurology · 2023Article
- Indomethacin-Induced Headache: Causing the Problem You Are Trying to Solve.Current pain and headache reports · 2021Review
- Review
- Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review.Nutrients · 2021Review
- The fifth cranial nerve in headaches.The journal of headache and pain · 2020Review
- Role of Mitochondrial Stress Protein HSP60 in Diabetes-Induced Neuroinflammation.Mediators of inflammation · 2020Review
- Treatment of Recurrent Painful Ophthalmoplegic Neuropathy: A Case Where Pregabalin Was Successfully Employed.Case reports in neurological medicine · 2019Article
- Hemicrania Continua: a Clinical Perspective on Diagnosis and Management.Current neurology and neuroscience reports · 2018Review
- The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- A cyclic pathway of P2 × 7, bradykinin, and dopamine receptor activation induces a sustained articular hyperalgesia in the knee joint of rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Article
- Molecular detection of inflammation in cell models using hyperpolarizedTheranostics · 2018Article
- Effect of indomethacin-loaded nanocapsules incorporation in a dentin adhesive resin.Clinical oral investigations · 2017Article
- Amelioration of oxidative and inflammatory changes by Swertia chirayita leaves in experimental arthritis.Inflammopharmacology · 2016Article
- Do trigeminal autonomic cephalalgias represent primary diagnoses or points on a continuum?Current pain and headache reports · 2015Review
- Alzheimer's Disease: Exploring the Role of Inflammation and Implications for Treatment.International journal of Alzheimer's disease · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indomethacin, as a member of the non-steroidal anti-inflammatory drug class, plays a special role in the treatment of headaches. By definition, it is completely efficacious in the treatment of the primary headache disorders paroxysmal hemicrania and hemicrania continua. Therefore, indomethacin is also used as a tool for differential diagnosis in headache clinics. Indomethacin has a clear action as a cyclooxygenase inhibitor. Additional mechanisms and interactions with cell signaling pathways and inflammatory pathways are considered in this article. However, it is not known what mechanism or interaction with pathophysiological mechanisms is the key to indomethacin's specific pharmacology in headache therapy. Focusing on headache therapy, we summarize the current knowledge of pharmacology, treatment options, and recommendations for the use of indomethacin in primary headaches. New findings from the field of headache research, as well as from Alzheimer's disease and cancer research on the pharmacological actions of indomethacin and their potential implications on the pathophysiology of indomethacin sensitive headaches, are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.