ArticleJournal of the Association for Research in Otolaryngology : JARO2013
Regenerated synapses between postnatal hair cells and auditory neurons.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Engineering of functional auditory neurons from human induced pluripotent stem cells.Military Medical Research · 2026Article
- Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation.Molecular psychiatry · 2025Article
- Auditory hair cells and spiral ganglion neurons regenerate synapses with refined release properties in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Auditory Hair Cells and Spiral Ganglion Neurons Regenerate Synapses with Refined Release Properties In Vitro.bioRxiv : the preprint server for biology · 2023Article
- Article
- Opposite Roles of NT-3 and BDNF in Synaptic Remodeling of the Inner Ear Induced by Electrical Stimulation.Cellular and molecular neurobiology · 2021Article
- Trk agonist drugs rescue noise-induced hidden hearing loss.JCI insight · 2021Article
- An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure.Scientific reports · 2021Article
- Neurite Extension and Orientation of Spiral Ganglion Neurons Can Be Directed by Superparamagnetic Iron Oxide Nanoparticles in a Magnetic Field.International journal of nanomedicine · 2021Article
- Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure.Drug design, development and therapy · 2020Article
- Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss.Neural plasticity · 2020Review
- Altered expression of genes regulating inflammation and synaptogenesis during regrowth of afferent neurons to cochlear hair cells.PloS one · 2020Article
- Hearing regeneration and regenerative medicine: present and future approaches.Archives of medical science : AMS · 2019Article
- Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function.Scientific reports · 2019Article
- Advantageous environment of micro-patterned, high-density complementary metal-oxide-semiconductor electrode array for spiral ganglion neurons cultured in vitro.Scientific reports · 2018Article
- Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research.Journal of visualized experiments : JoVE · 2017Article
- Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.Molecular psychiatry · 2017Article
- Downregulation of miR-210 protected bupivacaine-induced neurotoxicity in dorsal root ganglion.Experimental brain research · 2016Article
- Imipramine protects retinal ganglion cells from oxidative stress through the tyrosine kinase receptor B signaling pathway.Neural regeneration research · 2016Article
- Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation.Neural plasticity · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Regeneration of synaptic connections between hair cells and spiral ganglion neurons would be required to restore hearing after neural loss. Here we demonstrate by immunohistochemistry the appearance of afferent-like cochlear synapses in vitro after co-culture of de-afferented organ of Corti with spiral ganglion neurons from newborn mice. The glutamatergic synaptic complexes at the ribbon synapse of the inner hair cell contain markers for presynaptic ribbons and postsynaptic densities. We found postsynaptic density protein PSD-95 at the contacts between hair cells and spiral ganglion neurons in newly formed synapses in vitro. The postsynaptic proteins were directly facing the CtBP2-positive presynaptic ribbons of the hair cells. BDNF and NT-3 promoted afferent synaptogenesis in vitro. Direct juxtaposition of the postsynaptic densities with the components of the preexisting ribbon synapse indicated that growing fibers recognized components of the presynaptic sites. Initiation of cochlear synaptogenesis appeared to be influenced by glutamate release from the hair cell ribbons at the presynaptic site since the synaptic regeneration was impaired in glutamate vesicular transporter 3 mutant mice. These insights into cochlear synaptogenesis could be relevant to regenerative approaches for neural loss in the cochlea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.