ArticleThe Analyst2013
The chemical origin of enhanced signals from tip-enhanced Raman detection of functionalized nanoparticles.
Article in The Analyst, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Self-Assembled Rhodium Nanoantennas for Single-Protein UV SERS.Nanophotonics (Berlin, Germany) · 2026Article
- From the lab to the field: handheld surface enhanced Raman spectroscopy (SERS) detection of viral proteins.Sensors & diagnostics · 2023Article
- Accessible hotspots for single-protein SERS in DNA-origami assembled gold nanorod dimers with tip-to-tip alignment.Nature communications · 2023Article
- Tip-Enhanced Raman Spectroscopy with High-Order Fiber Vector Beam Excitation.Sensors (Basel, Switzerland) · 2018Article
- Probing Membrane Receptors with Enhanced Raman Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Spectroscopic Imaging at the Nanoscale: Technologies and Recent Applications.Analytical chemistry · 2018Review
- Elucidating Protein/Ligand Recognition with Combined Surface Plasmon Resonance and Surface Enhanced Raman Spectroscopy.Analytical chemistry · 2017Article
- Bioanalytical applications of surface-enhanced Raman spectroscopy:Reviews in analytical chemistry · 2017Article
- Probing Membrane Receptor-Ligand Specificity with Surface- and Tip- Enhanced Raman Scattering.Analytical chemistry · 2017Article
- Selective Detection of RGD-Integrin Binding in Cancer Cells Using Tip Enhanced Raman Scattering Microscopy.Analytical chemistry · 2016Article
- Targeted-TERS detection of integrin receptors on human cancer cells.Cancer cell & microenvironment · 2016Article
- Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing.Sensors (Basel, Switzerland) · 2015Review
- Experimental correlation of electric fields and Raman signals in SERS and TERS.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Selective TERS detection and imaging through controlled plasmonics.Faraday discussions · 2015Article
- Imaging Electric Fields in SERS and TERS Using the Vibrational Stark Effect.The journal of physical chemistry letters · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Here we present results that investigate the origins of signals observed in tip-enhanced Raman (TERS) measurements of functionalized nanoparticles. Surface enhanced Raman scattering (SERS) is known to give the largest enhancements in gap junctions. Similarly, gap-mode TERS also produces significant enhancements. The methodology developed here provides gap-mode like enhancements in TERS measurements without the need for a metal surface. Using a combination of aggregated nanoparticle SERS and TERS detection of functionalized nanoparticles, we assess the chemical origins of the observed peaks and show that molecules outside of gap junctions are also enhanced using our methodology. Our experiments use biotin and streptavidin as a model system for protein-ligand binding. Different size functionalized nanoparticles (20, 50, 80 nm) show changes in intensity in both SERS and TERS measurements. SERS measurements indicate that streptavidin has a larger Raman cross-section than biotin and is preferentially observed. The specific streptavidin peaks observed by TERS vary depending on whether streptavidin is attached to the nanoparticle and located in the gap or bound to the substrate surface. This methodology suggests a route to enhancing TERS signals associated with protein receptors in biological systems that cannot be isolated to a metallic surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.