ArticleNeurochemical research2013
Sciatic nerve transection modulates oxidative parameters in spinal and supraspinal regions.
Article in Neurochemical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Ultrasonographic assessment of skeletal muscles after experimentally induced neurogenic inflammation (facet injury) in rats.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation.Metabolic brain disease · 2020Article
- Evaluation of the effect of chiropractic manipulative treatment on oxidative stress in sacroiliac joint dysfunction.Turkish journal of physical medicine and rehabilitation · 2020Article
- Treatment with ascorbic acid and α-tocopherol modulates oxidative-stress markers in the spinal cord of rats with neuropathic pain.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Effects of Methanol Fraction from Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat.BMC neurology · 2017Article
- Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Nitroxidative Signaling Mechanisms in Pathological Pain.Trends in neurosciences · 2016Review
- Anti-allodynic effect of theoesberiven F in a vincristine-induced neuropathy model.Experimental and therapeutic medicine · 2016Article
- Cancer-induced bone pain: Mechanisms and models.Neuroscience letters · 2013Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain is a very common dysfunction caused by several types of nerve injury. This condition leads to a variety of pathological changes in central nervous system regions related to pain transmission. It has been demonstrated that nociception is modulated by reactive oxidative species and treatments with antioxidant compounds produce antinociceptive effects. Thus, the aim of the present study was to investigate oxidative parameters in spinal and supraspinal regions following sciatic nerve transection (SNT). In behavioral assessments, animals showed mechanical allodynia and a significant functional impairment following SNT, measured by von Frey hairs test and sciatic functional index, respectively. Superoxide dismutase activity was increased 3 and 7 days following SNT in cerebral cortex and brainstem. Catalase activity was also increased in cerebral cortex 3 days after SNT. Ascorbic acid levels were decreased 7 days in the spinal cord only in SNT group. We also showed an increase in lipid peroxidation in cerebral cortex and brainstem 3 days after surgery in SNT and sham groups. These results showed that supraspinal regions also exhibit changes in antioxidant activity after SNT and demonstrate an intricate relationship among antioxidant defenses in different regions of the neuro axis related to pain transmission.
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