ArticleBrain structure & function2014
Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum.
Article in Brain structure & function, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Body temperature regulates glucose metabolism and torpid behavior.Nature communications · 2025Article
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- α-Pinene Influence on Pulpal Pain-Induced Learning and Memory Impairment in Rats Via Modulation of the GABAA Receptor.Advanced biomedical research · 2022Article
- Illuminating subcortical GABAergic and glutamatergic circuits for reward and aversion.Neuropharmacology · 2021Review
- Lateral preoptic area neurons signal cocaine self-administration behaviors.The European journal of neuroscience · 2021Article
- Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway.Molecular psychiatry · 2021Article
- Projections from the nucleus accumbens shell to the ventral pallidum are involved in the control of sucrose intake in adult female rats.Brain structure & function · 2020Article
- Inactivation of the Ventral Pallidum by GABANeurochemical research · 2020Article
- Dissociable effects of dopamine D1 and D2 receptors on compulsive ingestion and pivoting movements elicited by disinhibiting the ventral pallidum.Brain structure & function · 2019Article
- The lateral preoptic area and ventral pallidum embolden behavior.Brain structure & function · 2019Article
- The Lateral Preoptic Area: A Novel Regulator of Reward Seeking and Neuronal Activity in the Ventral Tegmental Area.Frontiers in neuroscience · 2019Article
- Lateral preoptic and ventral pallidal roles in locomotion and other movements.Brain structure & function · 2018Article
- Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure.eLife · 2018Article
- Abundant collateralization of temporal lobe projections to the accumbens, bed nucleus of stria terminalis, central amygdala and lateral septum.Brain structure & function · 2017Article
- Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat.The Journal of comparative neurology · 2015Article
- The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors.Progress in neurobiology · 2015Review
- Modulation of locomotor activation by the rostromedial tegmental nucleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Sensitivity to self-administered cocaine within the lateral preoptic-rostral lateral hypothalamic continuum.Brain structure & function · 2015Article
- Protracted maturation of forebrain afferent connections of the ventral tegmental area in the rat.The Journal of comparative neurology · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ambulatory locomotion in the rodent is robustly activated by unilateral infusions into the basal forebrain of type A gamma-aminobutyric acid receptor antagonists, such as bicuculline and picrotoxin. The present study was carried out to better localize the neuroanatomical substrate(s) underlying this effect. To accomplish this, differences in total locomotion accumulated during a 20-min test period following bicuculline versus saline infusions in male Sprague-Dawley rats were calculated, rank ordered and mapped on a diagram of basal forebrain transposed from immunoprocessed sections. The most robust locomotor activation was elicited by bicuculline infusions clustered in rostral parts of the preoptic area. Unilateral infusions of bicuculline into the ventral pallidum produced an unanticipatedly diminutive activation of locomotion, which led us to evaluate bilateral ventral pallidal infusions, and these also produced only a small activation of locomotion, and, interestingly, a non-significant trend toward suppression of rearing. Subjects with bicuculline infused bilaterally into the ventral pallidum also exhibited persistent bouts of abnormal movements. Bicuculline infused unilaterally into other forebrain structures, including the bed nucleus of stria terminalis, caudate-putamen, globus pallidus, sublenticular extended amygdala and sublenticular substantia innominata, did not produce significant locomotor activation. Our data identify the rostral preoptic area as the main substrate for the locomotor-activating effects of basal forebrain bicuculline infusions. In contrast, slight activation of locomotion and no effect on rearing accompanied unilateral and bilateral ventral pallidal infusions. Implications of these findings for forebrain processing of reward are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.