ArticleClinical endoscopy2013
Peroral endoscopic myotomy for treating achalasia in an animal model: a feasibility study.
Article in Clinical endoscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Pilot prospective study on formal training in per-oral endoscopic myotomy (POEM) during advanced endoscopy fellowship.Endoscopy international open · 2021Article
- Factors predicting the technical difficulty of peroral endoscopic myotomy for achalasia.Surgical endoscopy · 2016Article
- International digestive endoscopy network 2014: turnpike to the future.Clinical endoscopy · 2014Review
- Peroral endoscopic myotomy in a porcine model: a step to achalasia patients.Clinical endoscopy · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsLaparoscopic Heller myotomy with antireflux procedure is considered to be a standard treatment for achalasia. Recently, peroral endoscopic myotomy (POEM) was developed and performed on patients with achalasia. However, there is no report on POEM use in South Korea. The aim of this study was to evaluate the technical feasibility of POEM in a porcine model.
methodsPOEM was performed on two mini pigs. We performed upper endoscopy under general anesthesia. A submucosal tunnel was created and the circular muscle layer was incised using several knives. The mucosal entry was closed using resolution clips. We performed a follow-up endoscopy and sacrificed the pigs 2 weeks after the POEM. The myotomy site was evaluated grossly and histologically.
resultsPOEM was successfully performed on the two mini pigs. No injuries to any abdominal or mediastinal structures occurred. Two weeks after the POEM, the esophageal mucosa healed without any endoscopic evidence of complications. Necropsy revealed that the circular muscle layer was completely lost and replaced with fibrotic tissue.
conclusionsWe found that POEM is a technically feasible method which can be performed on an animal model. However, to ensure safe use on patients with achalasia, further studies on technical methods and long-term follow-up examinations are required.
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