ArticleTranslational psychiatry2013
Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene.
Article in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 7 syntheses or guidelines pooled it, 315 citations in OpenAlex.
- Epigenetic mechanisms affected by stress during adolescence and the increased risk for depression later in life: a systematic review.Molecular psychiatry · 2026Pooled it
- Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review.Neuroscience and biobehavioral reviews · 2023Pooled it
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature.European child & adolescent psychiatry · 2020Pooled it
- The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- The Effects of Individual Psychotherapy in BDNF Levels of Patients With Mental Disorders: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Measuring the shadows: A systematic review of chronic emptiness in borderline personality disorder.PloS one · 2020Pooled it
- Trial
- Dynamic functional connectivity in borderline personality disorder: associations with trauma, emotion regulation and symptom severity.European archives of psychiatry and clinical neuroscience · 2026Article
- Maternal separation increases anxiety-like phenotypes, fear responses, and altersNeurobiology of stress · 2026Article
- Epigenetic regulation of brain development, plasticity, and response to early-life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The Epigenetic Landscape of Borderline Personality Disorder: Insights from a Systematic Review.Journal of clinical medicine · 2025Review
- Changes in DNA Methylation Associated With Psychobehavioral Interventions: A Scoping Literature Review.Biological research for nursing · 2025Article
- InvestigatingBrain sciences · 2025Article
- Internalizing and Externalizing Traits During Adolescence: Using Epigenetics and Perinatal Risks to Differentiate Clusters of Symptoms.Biomolecules · 2025Article
- Borderline personality: revisiting its classification as a neurodevelopmental disorder.Frontiers in psychiatry · 2025Review
- Gene Expression After Exercise Is Disrupted by Early-Life Stress.Developmental psychobiology · 2025Article
- Computer-aided Drug Discovery of Epigenetic Modulators in Dual-target Therapy of Multifactorial Diseases.Current topics in medicinal chemistry · 2025Review
- Differential methylation of OPRK1 in borderline personality disorder is associated with childhood trauma.Molecular psychiatry · 2024Article
- DNA Methylation ofBiomolecules · 2024Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Downregulation of brain-derived neurotrophic factor (BDNF) gene expression with corresponding increased methylation at specific promoters has been associated with stressful experiences in early life and may explain later adulthood psychopathology. We measured the percentage of methylation at BDNF CpG exons I and IV as well as plasma BDNF protein levels in 115 subjects with borderline personality disorder (BPD) and 52 controls. BPD subjects then underwent a 4-week course of intensive dialectical behavior therapy (I-DBT). BDNF methylation status and protein levels were re-assessed at the end of treatment. BPD subjects had significantly higher methylation status in both CpG regions than controls. In addition, the higher the number of childhood trauma, the higher was the methylation status. In BPD subjects, BDNF methylation significantly increased after I-DBT. Nonresponders accounted for the majority of this increase, whereas responders showed a decrease in methylation status over time. Accordingly, the changes in methylation status over time were significantly associated with changes in depression scores, hopelessness scores and impulsivity. No association was found between protein levels and BDNF methylation status. We here found a relationship between child maltreatment and higher DNA methylation of BDNF. These results moreover support the idea that these epigenetic marks may be changed through psychotherapeutic approaches and that these changes underline changes in cognitive functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.