ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Family-based study of AVPR1B association and interaction with stressful life events on depression and anxiety in suicide attempts.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Arginine-vasopressin systems in autistic phenotype schizophrenia: effect of a genetic variant of AVPR1a and AVPR1b.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Plasma copeptin is coupled to resting-state frontoinsular-subgenual alpha dynamics in major depression with comorbid post-traumatic stress disorder.Frontiers in endocrinology · 2026Article
- A pharmacological and brain imaging study of human vasopressin AVP1BR receptor functional polymorphisms.BMC neuroscience · 2025Article
- A Three-Way Interaction of Sex, PER2Genes · 2023Article
- Multiple Aspects of Inappropriate Action of Renin-Angiotensin, Vasopressin, and Oxytocin Systems in Neuropsychiatric and Neurodegenerative Diseases.Journal of clinical medicine · 2022Review
- The Biology of Vasopressin.Biomedicines · 2021Review
- Advances in novel molecular targets for antidepressants.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Polymorphisms of stress pathway genes and emergence of suicidal ideation at antidepressant treatment onset.Translational psychiatry · 2020Article
- Chromosome-level de novo assembly of the pig-tailed macaque genome using linked-read sequencing and HiC proximity scaffolding.GigaScience · 2020Article
- Precision medicine for suicidality: from universality to subtypes and personalization.Molecular psychiatry · 2017Article
- The Relationship between Ghrelin and Copeptin Levels, and Anxiety and Depression Levels in Suicide Attempts.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Polygenic associations of neurodevelopmental genes in suicide attempt.Molecular psychiatry · 2016Article
- Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions.Frontiers in psychiatry · 2016Review
- Article
- The Vasopressin 1b Receptor Antagonist A-988315 Blocks Stress Effects on the Retrieval of Object-Recognition Memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- An overview of the neurobiology of suicidal behaviors as one meta-system.Molecular psychiatry · 2015Review
- The association of proopiomelanocortin polymorphisms with the risk of major depressive disorder and the response to antidepressants via interactions with stressful life events.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Association, haplotype, and gene-gene interactions of the HPA axis genes with suicidal behaviour in affective disorders.TheScientificWorldJournal · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cortisol response to psychosocial stress may become dysregulated in stress-related disorders. It is potentiated by pituitary secretion of adrenocorticotropic hormone (ACTH), which is, in part, regulated by arginine vasopressin receptor-1B (AVPR1B). AVPR1B variants were previously reported to associate with mood and anxiety disorders. This study aims, for the first time, to investigate association of AVPR1B genetic variants with mood and anxiety outcomes in suicidal behavior.Using a family-based study design of 660 complete nuclear family trios with offspring who have made a suicide attempt (SA), we tested the direct association and linkage of AVPR1B single nucleotide polymorphisms (SNPs) with SA, as well as with depression and anxiety in SA. Main findings were the association and linkage of AVPR1B exon 1 SNP rs33990840 and a major 6-SNP haplotype representative of all common AVPR1B-SNPs, on the outcome of high Beck Depression Inventory scores in SA. By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. An exploratory screen of interactions between AVPR1B and CRHR1 (corticotropin-releasing hormone receptor-1), the principal pituitary regulator of ACTH secretion, showed no support for gene-gene interactions on the studied outcomes. The results suggest that AVPR1B genetic variation, eg, non-synonymous SNP rs33990840 mediating putative consequences on ligand binding, has a role in SA etiology characterized by elevated depression symptoms, without involving AVPR1B-moderation of SLEs.
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