Evidence map›Paper›PMID 23422418›Full record

ReviewMechanisms of ageing and development

Structure, function and regulation of CSB: a multi-talented gymnast.

Robert J Lake, Hua-Ying Fan

Open access · greenAbstract readReview
In one paragraph

Review in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 51 citations in OpenAlex.

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  14. Two heterozygous mutations in theThe Journal of international medical research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert J LakeEpigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hua-Ying Fan
University of Pennsylvania · US

Funding

Basis for Distinct Functions of ATP-Dependent Chromatin Remodeling ComplexesR01GM084983 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI FAN, HUA-YING · 2008 to 2012
$1.6M
NIGMS NIH HHS GM 084983NIGMS NIH HHS R01 GM084983
6 · The paper itself

Abstract

The Cockayne syndrome complementation group B protein, CSB, plays pivotal roles in transcription regulation and DNA repair. CSB belongs to the SNF2/SWI2 ATP-dependent chromatin remodeling protein family, and studies from many laboratories have revealed that CSB has multiple activities and modes of regulation. To understand the underlying mechanisms of Cockayne syndrome, it is necessary to understand how the biochemical activities of CSB are used to carry out its biological functions. In this review, we summarize our current knowledge of the structure, function and regulation of CSB, and discuss how these properties can impact the biological functions of this chromatin remodeler.

Indexed as

AnimalsChromatin Assembly and DisassemblyDNA HelicasesDNA RepairDNA Repair EnzymesHumansPoly-ADP-Ribose Binding ProteinsStructure-Activity RelationshipTranscription, GeneticDNA HelicasesDNA Repair EnzymesERCC6 protein, humanPoly-ADP-Ribose Binding Proteins

Identifiers

PMID23422418
PMCPMC3750219
OpenAlexW2071396949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.