ArticleLearning & memory (Cold Spring Harbor, N.Y.)2013
Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuits.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- Selective Modulation of Fear Memory in Non-Rapid Eye Movement Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Fear attenuation collaborations to optimize translation.Behavioral neuroscience · 2024Article
- Carbon Dioxide Reactivity Differentially Predicts Fear Expression After Extinction and Retrieval-Extinction in Rats.Biological psychiatry global open science · 2024Article
- Reconsolidation and Fear Extinction: An Update.Current topics in behavioral neurosciences · 2023Article
- Unrelenting Fear Under Stress: Neural Circuits and Mechanisms for the Immediate Extinction Deficit.Frontiers in systems neuroscience · 2022Review
- Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?International journal of molecular sciences · 2021Review
- Behavioral and immunohistochemical characterization of rapid reconditioning following extinction of contextual fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- The immediate extinction deficit occurs in a nonemotional learning paradigm.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Transcriptional Regulation Involved in Fear Memory Reconsolidation.Journal of molecular neuroscience : MN · 2018Review
- Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats.Scientific reports · 2018Article
- Noradrenergic Modulation of Fear Conditioning and Extinction.Frontiers in behavioral neuroscience · 2018Review
- β-Adrenoceptor Blockade in the Basolateral Amygdala, But Not the Medial Prefrontal Cortex, Rescues the Immediate Extinction Deficit.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- A preregistered, direct replication attempt of the retrieval-extinction effect in cued fear conditioning in rats.Neurobiology of learning and memory · 2017Article
- Reconsolidation and psychopathology: Moving towards reconsolidation-based treatments.Neurobiology of learning and memory · 2017Review
- Memory Reconsolidation Interference as an Emerging Treatment for Emotional Disorders: Strengths, Limitations, Challenges, and Opportunities.Annual review of clinical psychology · 2017Review
- An Additional Prior Retrieval Alters the Effects of a Retrieval-Extinction Procedure on Recent and Remote Fear Memory.Frontiers in behavioral neuroscience · 2017Article
- Retrieval and Reconsolidation Accounts of Fear Extinction.Frontiers in behavioral neuroscience · 2016Article
- Stress and Fear Extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Prefrontal inputs to the amygdala instruct fear extinction memory formation.Science advances · 2015Article
- The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.Frontiers in behavioral neuroscience · 2015Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
An issue of increasing theoretical and translational importance is to understand the conditions under which learned fear can be suppressed, or even eliminated. Basic research has pointed to extinction, in which an organism is exposed to a fearful stimulus (such as a context) in the absence of an expected aversive outcome (such as a shock). This extinction process results in the suppression of fear responses, but is generally thought to leave the original fearful memory intact. Here, we investigate the effects of extinction during periods of memory lability on behavioral responses and on expression of the immediate-early gene c-Fos within fear conditioning and extinction circuits. Our results show that long-term extinction is impaired when it occurs during time periods during which the memory should be most vulnerable to disruption (soon after conditioning or retrieval). These behavioral effects are correlated with hyperactivation of medial prefrontal cortex and amygdala subregions associated with fear expression rather than fear extinction. These findings demonstrate that behavioral experiences during periods of heightened fear prevent extinction and prolong the conditioned fear response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.