ArticleVascular cell2013
The importance of microglia in the development of the vasculature in the central nervous system.
Article in Vascular cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed.
- The Epidermal Growth Factor Receptor (EGFR) as a means of neuro-immune cross-conversation.Journal of neuroinflammation · 2026Review
- Polyunsaturated Fatty Acid Balance Modulates Microglial State in a Murine Model of Oxygen-Induced Neovascularization.Nutrients · 2026Article
- Microglia in retinal vascular diseases: inflammatory mechanism and therapeutic target.International journal of ophthalmology · 2026Review
- Polyunsaturated fatty acid balance modulates microglial state in a murine model of oxygen-induced neovascularization.Research square · 2025Article
- Review
- Physiological and injury-induced microglial dynamics across the lifespan.Cell reports · 2025Article
- Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Perivascular macrophages in the central nervous system: insights into their roles in health and disease.Cell death & disease · 2025Review
- Morphological and Molecular Biological Changes in the Hippocampus and Prefrontal Cortex of the Brain of Newborn Male and Female Wistar Rats after LPS-Induced Activation of the Maternal Immune Response.Bulletin of experimental biology and medicine · 2025Article
- Astrocytes and microglia in the coordination of CNS development and homeostasis.Journal of neurochemistry · 2024Review
- Brain Maturation as a Fundamental Factor in Immune-Neurovascular Interactions in Stroke.Translational stroke research · 2024Review
- Developmental Associations between Neurovascularization and Microglia Colonization.International journal of molecular sciences · 2024Review
- The ins and outs of microglial cells in brain health and disease.Frontiers in immunology · 2024Review
- Roles in Innate Immunity.Advances in neurobiology · 2024Review
- Microglia Colonization Associated with Angiogenesis and Neural Cell Development.Advances in neurobiology · 2024Review
- Contactomics of Microglia and Intercellular Communication.Advances in neurobiology · 2024Review
- Evolution of Microglia.Advances in neurobiology · 2024Article
- Microglial Dynamics, Blood-Brain Barrier Morphogenesis, and Developmental Toxicity:Current opinion in toxicology · 2023Article
- Noteworthy perspectives on microglia in neuropsychiatric disorders.Journal of neuroinflammation · 2023Review
- Dopamine signaling from ganglion cells directs layer-specific angiogenesis in the retina.Current biology : CB · 2023Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The body's vascular system is thought to have developed in order to supply oxygen and nutrients to cells beyond the reach of simple diffusion. Hence, relative hypoxia in the growing central nervous system (CNS) is a major driving force for the ingression and refinement of the complex vascular bed that serves it. However, even before the establishment of this CNS vascular system, CNS-specific macrophages (microglia) migrate into the brain. Recent studies in mice point to the fundamental importance of microglia in shaping CNS vasculature during development, and re-shaping these vessels during pathological insults. In this review, we discuss the origin of CNS microglia and their localization within the brain based on data obtained in mice. We then review evidence supporting a functional role of these microglia in developmental angiogenesis. Although pathologic processes such as CNS ischemia may subvert the developmental functions of microglia/macrophages with significant effects on brain neo-angiogenesis, we have left this topic to other recent reviews (Nat Rev Immunol 9:259-270, 2009 and Trends Mol Med 17:743-752, 2011).
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.