Evidence map›Paper›PMID 23422074›Full record

ArticleFEBS letters2013

Effect of cargo size and shape on the transport efficiency of the bacterial Tat translocase.

Neal Whitaker, Umesh Bageshwar, Siegfried M Musser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Neal WhitakerDepartment of Molecular and Cellular Medicine, College of Medicine, The Texas A&M Health Science Center, 1114 TAMU, College Station, TX 77843, USA.
Umesh Bageshwar
Siegfried M Musser

Funding

Single Molecule Analysis of Bacterial Protein TransportR01GM065534 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MUSSER, SIEGFRIED M · 2003 to 2010
$1.6M
NIGMS NIH HHS GM065534NIGMS NIH HHS R01 GM065534
6 · The paper itself

Abstract

The Tat machinery translocates fully-folded and oligomeric substrates. The passage of large, bulky cargos across an ion-tight membrane suggests the need to match pore and cargo size, and therefore that Tat transport efficiency may depend on both cargo size and shape. A series of cargos of different sizes and shapes were generated using the natural Tat substrate pre-SufI as a base. Four (of 17) cargos transported with significant (>20% of wild-type) efficiencies. These results indicate that cargo size and shape significantly influence Tat transportability.

Indexed as

Biological TransportBlotting, WesternCell MembraneCysteineEscherichia coliEscherichia coli ProteinsGreen Fluorescent ProteinsKineticsLuminescent MeasurementsMembrane Transport ProteinsModels, MolecularMolecular WeightMutationProtein ConformationProtein PrecursorsCysteineEscherichia coli ProteinsGreen Fluorescent ProteinsMembrane Transport ProteinsProtein PrecursorsSufI protein, E coliTatA protein, E coliTatB protein, E coliTatC protein, E coli

Identifiers

PMID23422074
PMCPMC3613985

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.