ReviewTrends in genetics : TIG2013
Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people.
Review in Trends in genetics : TIG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Clinical, cellular, and genomic consequences of a population-enrichedResearch square · 2026Article
- Heritability, phenotypic, and genetic correlations across dimensional and categorical models of bipolar disorder in a family sample.Journal of affective disorders · 2025Article
- A resource of induced pluripotent stem cell (iPSC) lines including clinical, genomic, and cellular data from genetically isolated families with mood and psychotic disorders.Translational psychiatry · 2023Article
- Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population.Molecular psychiatry · 2023Article
- Physical health conditions of the Amish and intervening social mechanisms: an exhaustive narrative review.Ethnicity & health · 2022Review
- The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish.HGG advances · 2022Article
- The GGLEAM Study: Understanding Glaucoma in the Ohio Amish.International journal of environmental research and public health · 2021Article
- Research Trends in Amish Population Health, a Growing Literature about a Growing Rural Population.Journal of rural social sciences · 2021Article
- The genetics of bipolar disorder.Molecular psychiatry · 2020Review
- Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Rediscovering the value of families for psychiatric genetics research.Molecular psychiatry · 2019Review
- Genetic pleiotropy between mood disorders, metabolic, and endocrine traits in a multigenerational pedigree.Translational psychiatry · 2018Article
- A population-specific reference panel empowers genetic studies of Anabaptist populations.Scientific reports · 2017Article
- The Sardinian Puzzle: Concentration of Major Psychoses and Suicide in the Same Sub-Regions Across One Century.Clinical practice and epidemiology in mental health : CP & EMH · 2017Article
- Symptom profiles and illness course among Anabaptist and Non-Anabaptist adults with major mood disorders.International journal of bipolar disorders · 2016Article
- Commonalities in Development of Pure Breeds and Population Isolates Revealed in the Genome of the Sardinian Fonni's Dog.Genetics · 2016Article
- Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder.BMC genetics · 2015Article
- A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.Human molecular genetics · 2014Article
- Genetics of Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The rapid development of next-generation sequencing (NGS) technology has led to renewed interest in the potential contribution of rarer forms of genetic variation to complex non-mendelian phenotypes such as psychiatric illnesses. Although challenging, family-based studies offer some advantages, especially in communities with large families and a limited number of founders. Here we revisit family-based studies of mental illnesses in traditional Amish and Mennonite communities--known collectively as the Plain people. We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.