Evidence map›Paper›PMID 23422033›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2013

Resveratrol enhances exercise training responses in rats selectively bred for high running performance.

Nikolett Hart, Linda Sarga, Zsolt Csende, Erika Koltai, Lauren G Koch, Steven L Britton, Kelvin J A Davies, Dimitris Kouretas, Barbara Wessner, Zsolt Radak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 92 citations in OpenAlex.

  1. Trial
  2. Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Trial
  3. Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015
    Trial
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Review
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  10. Review
  11. Article
  12. Review
  13. Resveratrol and Wine: An Overview of Thirty Years in the Digital News.International journal of environmental research and public health · 2022
    Article
  14. CoQNutrients · 2022
    Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Nikolett HartResearch Institute of Sport Science, Semmelweis University, Budapest, Hungary.
Linda Sarga
Zsolt Csende
Erika Koltai
Lauren G Koch
Steven L Britton
Kelvin J A Davies
Dimitris Kouretas
Barbara Wessner
Zsolt Radak
Semmelweis University · HUUniversity of Michigan–Ann Arbor · USUniversity of Southern California · USUniversity of Thessaly · GRUniversity of Vienna · AT

Funding

RESOURCE FOR RAT GENETIC MODELS OF AEROBIC CAPACITYR24RR017718 · NCRR · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI BRITTON, STEVEN LOYAL · 2003 to 2011
$4.0M
Biology of Aerobic Capacity and Insulin ResistanceR01DK077200 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2008 to 2012
$1.5M
Resource for Rat Genetic Models of Aerobic CapacityR24OD010950 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRITTON, STEVEN LOYAL · 2012 to 2013
$1.0M
NCRR NIH HHS R24 RR017718NIDDK NIH HHS R01 DK077200NIH HHS R24 OD010950
6 · The paper itself

Abstract

High Capacity Runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12 weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p<0.05). The changes in mitochondrial fission/fusion and Lon protease/HSP78 levels suggest that exercise training does not significantly induce damage of proteins. Moreover, neither exercise training nor resveratrol supplementation altered the content of protein carbonyls. Changes in the levels of forkhead transcription factor 1 and SIRT4 could suggest increased fat utilization and improved insulin sensitivity. These data indicate, that resveratrol supplementation enhances aerobic performance due to the activation of the AMPK-SIRT1-PGC-1α pathway.

Indexed as

AMP-Activated Protein KinasesAnimalsAntioxidantsBiomarkersDNA-Binding ProteinsInsulin ResistanceMaleMitochondriaMitochondrial ProteinsOxidative StressPhysical Conditioning, AnimalProtein CarbonylationRatsReactive Oxygen SpeciesResveratrolRunningAMP-Activated Protein KinasesAntioxidantsBiomarkersDNA-Binding ProteinsMitochondrial Proteinsmitochondrial transcription factor AReactive Oxygen SpeciesResveratrolSirt1 protein, ratSirtuin 1StilbenesTranscription FactorsEndurance exerciseEpigeneticsMitochondrial biogenesisOxidative stressPGC1-alphaResveratrol

Identifiers

PMID23422033
PMCPMC3703486
OpenAlexW2005375864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.