ArticleJournal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)2013
Impact of child sex abuse on adult psychopathology: a genetically and epigenetically informed investigation.
Article in Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- Childhood or adolescent abuse and primary open-angle glaucoma in a longitudinal cohort of women.Eye (London, England) · 2025Article
- Evaluating the challenges and reproducibility of studies investigating DNA methylation signatures of psychological stress.Epigenomics · 2022Review
- Epigenomic mediation after adverse childhood experiences: a systematic review and meta-analysis.Forensic sciences research · 2021Review
- Evolution of brain-wide activity in the awake behaving mouse after acute fear by longitudinal manganese-enhanced MRI.NeuroImage · 2020Article
- The Genome-Wide Study of Human Social Behavior and Its Application in Sociology.Frontiers in sociology · 2019Review
- Genes and Aggressive Behavior: Epigenetic Mechanisms Underlying Individual Susceptibility to Aversive Environments.Frontiers in behavioral neuroscience · 2018Review
- Methodological Challenges in Developmental Human Behavioral Epigenetics: Insights Into Study Design.Frontiers in behavioral neuroscience · 2018Article
- Exploring genetic moderators and epigenetic mediators of contextual and family effects: From Gene × Environment to epigenetics.Development and psychopathology · 2016Review
- Epigenetic pathways through which experiences become linked with biology.Development and psychopathology · 2015Review
- Childhood maltreatment and stress-related psychopathology: the epigenetic memory hypothesis.Current pharmaceutical design · 2015Review
- Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Genetic, environmental, and epigenetic influences and their transactions were examined in a sample of 155 women from the Iowa adoptee sample who had been removed from their biological parents shortly after birth and assessed when participants were an average of 41.10 years old. We observed an interactive effect of child sex abuse (CSA) and biological parent psychopathology (i.e., genetic load) on substance abuse as well as a main effect of CSA on substance abuse in adulthood. We also observed main effects of CSA and genetic load on depression and on antisocial characteristics. As predicted, CSA, but not genetic load or later substance abuse, was associated with epigenetic change. In addition, the interaction between genetic load and CSA predicted epigenetic change, indicating a potential genetic basis for a differential impact of CSA on epigenetic change. Finally, epigenetic change partially mediated the effect of CSA on antisocial characteristics. The results suggest the relevance of genetic and epigenetic processes for future theorizing regarding marital and family precursors of several forms of adult psychopathology. Implications for preventive intervention are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.