Evidence map›Paper›PMID 23421765›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2013

Smooth muscle cell Ca²⁺: think locally, act globally.

Scott Earley

Abstract readEditorial
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Scott EarleyVascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA. Scott.Earley@colostate.edu
Colorado State University · US

Funding

TRP Channel-Dependent Regulation of Arterial Tone (Renewal)R01HL091905 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2009 to 2020
$5.1M
NHLBI NIH HHS R01 HL091905NHLBI NIH HHS R01HL091905
6 · The paper itself

Abstract

Dynamic changes in intracellular Ca²⁺ levels in vascular smooth muscle cells are critically important for cardiovascular regulation. This Special Topic Issue highlights a series of expert opinion articles focused on this important subject. After a brief overview, novel discoveries surrounding smooth muscle cell Ca²⁺ influx via L-type and T-type channels are reviewed. Current work revealing the functional importance of dynamic Ca²⁺ signaling in the control of the parenchymal microvasculature and the emerging role of mitochondrial Ca²⁺ signaling and store-operated Ca²⁺ entry in smooth muscle cells is discussed. Finally, recent data describing a new target of localized Ca²⁺ signaling in arterial myocytes that is responsible for membrane depolarization is reviewed. Authors were encouraged to write in an opinionated and provocative manner with the hope of stimulating discussion in this area of research.

Indexed as

AnimalsCalciumCalcium Channels, L-TypeCalcium Channels, T-TypeCalcium SignalingHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleCalciumCalcium Channels, L-TypeCalcium Channels, T-Type

Identifiers

PMID23421765
PMCPMC5846468
OpenAlexW2014021134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.