ArticleMolecular microbiology2013
Dealing with change: the different microenvironments faced by the malarial parasite.
Article in Molecular microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii.PLoS pathogens · 2021Article
- Whole-Cell Phenotypic Screening of Medicines for Malaria Venture Pathogen Box Identifies Specific Inhibitors ofAntimicrobial agents and chemotherapy · 2020Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
In a new paper, Pillai et al. (2013) report that in vitro asexual blood-stage Plasmodium falciparum parasite cultures are able to grow unhindered in media with surprisingly broad ranges of ionic constituents. In doing so, the authors demonstrate that long known changes in the cationic composition of the cytosol of host erythrocytes induced by developing intra-erythrocytic parasites are not essential for growth. Moreover, their results also suggest that besides a low K(+) environment, which has been shown to trigger key processes such as microneme secretion and merozoite egress, there must be alternative signals that can regulate these processes and allow normal growth in diverse ionic environments. Given these findings, mechanisms by which the parasite is able to sense and tolerate different ionic environments are worthy of further study in an effort to identify urgently needed novel anti-malarial strategies.
Indexed as
Identifiers
23421761What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.