ArticleThyroid : official journal of the American Thyroid Association2013
Cancer risk in patients with Graves' disease: a nationwide cohort study.
Article in Thyroid : official journal of the American Thyroid Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 5 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.Nature genetics · 2026Pooled it
- Pooled it
- Genetically predicted alterations in thyroid function are associated with the risk of benign prostatic disease.Frontiers in endocrinology · 2023Pooled it
- Cancer Risk in Hashimoto's Thyroiditis: a Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2022Pooled it
- Association of benign thyroid diseases with thyroid cancer risk: a meta-analysis of prospective observational studies.Journal of endocrinological investigation · 2019Pooled it
- Impact of hypothyroidism and hyperthyroidism on endometrial cancer incidence: results from a large population-based cohort study.European journal of epidemiology · 2026Article
- 2‑Thiouracil Antithyroid Drug Delivery with Functionalized BCACS omega · 2025Article
- Process to radioactive iodine treatment for Graves' hyperthyroidism: condemned or absolved?Journal of endocrinological investigation · 2025Review
- Synchronous Presentation of Type 2 Marine-Lenhart Syndrome and Differentiated Thyroid Carcinoma Manifesting as Thyroid Storm.Case reports in endocrinology · 2025Article
- Navigating the thyroid-gynecologic interplay: a systematic review and meta-analysis.Obstetrics & gynecology science · 2024Article
- Association between thyroid disorders and extra-thyroidal cancers, a review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Review
- Recombinant Human TSH Fails to Induce the Proliferation and Migration of Papillary Thyroid Carcinoma Cell Lines.Cancers · 2024Article
- Risk of Thyroid Cancer in People With Type 1 Diabetes by Autoimmune Thyroid Diseases and Tumor Histology.Journal of the Endocrine Society · 2024Article
- Hypothyroidism and hyperthyroidism related to gynecologic cancers: a nationwide population-based cohort study.Scientific reports · 2024Article
- Radiation-Related Thyroid Cancer.Endocrine reviews · 2024Review
- Prevalence of Papillary Thyroid Carcinoma is Significantly Higher in Graves Disease with Synchronous Thyroid Nodules.Turk patoloji dergisi · 2024Article
- Case report: A rare combination of aldosterone-secreting adrenocortical carcinoma and papillary thyroid carcinoma with Graves' disease.Frontiers in endocrinology · 2024Article
- Causal effects of autoimmune diseases on thyroid cancer: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Thyroid hormones as biomarkers of lung cancer: a retrospective study.Annals of medicine · 2023Article
- Genetically predicted thyroid function and risk of colorectal cancer: a bidirectional Mendelian randomization study.Journal of cancer research and clinical oncology · 2023Article
13 more citing papers are in PubMed but not listed here.
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported.
methodsOur study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for GD patients was measured using the Cox proportional hazard model.
resultsThe incidence of developing cancer in the GD cohort was 4.92 per 1000 person-years and was 1.37-fold higher than in the comparison cohort (p<0.001). Compared with patients aged 20-34 years, older age groups demonstrated a higher risk of developing cancer (35-49 years: hazard ratio (HR)=4.15; 50-64 years: HR=7.39;≥65 years: HR=13.4). After adjusting for sex, age, and comorbidities, the HR for developing breast cancer and thyroid cancer was 1.58- and 10.4-fold higher for patients with GD. Furthermore, the incidence rates (IRR) were the highest in the first three years: 2.06 [confidence interval (CI)=1.87-2.27] and 15.6 [CI=13.9-17.5] in breast cancer and thyroid cancer with GD respectively. Specifically, a 16-fold hazard of developing thyroid cancer was present in the first three years in the GD cohort compared to the non-GD cohort [CI=7.95-32.1].
conclusionsGD patients have a higher risk of cancer, particularly thyroid and breast cancer sequent within six and three years respectively. Strategies for preventing thyroid and breast cancer are proposed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.