Trial reportJournal of obstetric, gynecologic, and neonatal nursing : JOGNN
Randomized, controlled trial evaluating a baby wash product on skin barrier function in healthy, term neonates.
Trial report in Journal of obstetric, gynecologic, and neonatal nursing : JOGNN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2022Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2021Pooled it
- Randomized trial with soaps - what happens to a newborn baby's skin?Jornal de pediatriaTrial
- Frequency of newborn bathing in the first 9 weeks of life and related factors: An observational study in a community-based sample from Meta-LARC.Pediatric dermatologyTrial
- Skin Care Practices in Indian Newborns and Infants: Current Scenario.Pediatric health, medicine and therapeutics · 2025Review
- Evidence-Based Consensus Recommendations for Skin Care in Healthy, Full-Term Neonates in India.Pediatric health, medicine and therapeutics · 2023Article
- Validity of Infant Face Skin Assessment by Parents at Home.Asian/Pacific Island nursing journal · 2020Article
- Recommendation for hygiene and topical in neonatology from the French Neonatal Society.European journal of pediatrics · 2019Article
- Noninvasive monitoring of plant-based formulations on skin barrier properties in infants with dry skin and risk for atopic dermatitis.International journal of women's dermatology · 2018Article
- Recommendations from a European Roundtable Meeting on Best Practice Healthy Infant Skin Care.Pediatric dermatology · 2016Review
- Clinical trials of medicines in neonates: the influence of ethical and practical issues on design and conduct.British journal of clinical pharmacology · 2015Review
- The Postpartum Maternal and Newborn Microbiomes.MCN. The American journal of maternal child nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the hypothesis that the use of a wash product formulated for newborn (<1 month of age) bathing is not inferior (no worse) to bathing with water only.
designAssessor-blinded, randomized, controlled, noninferiority trial.
settingA teaching hospital in the Northwest of England and in participants' homes.
participantsThree-hundred-and-seven healthy, term infants recruited within 48 hours of birth.
methodWe compared bathing with a wash product (n = 159) to bathing with water alone (n = 148). The primary outcome was transepidermal water loss (TEWL) at 14 days postbirth; the predefined difference deemed to be unimportant was 1.2. Secondary outcomes comprised changes in stratum corneum hydration, skin surface pH, clinical observations of the skin, and maternal views.
resultsComplete TEWL data were obtained for 242 (78.8%) infants. Wash was noninferior to water alone in terms of TEWL (intention-to-treat analysis: 95% confidence interval [CI] for difference [wash-water, adjusted for family history of eczema, neonate state, and baseline] -1.24, 1.07; per protocol analysis: 95% CI -1.42, 1.09). No significant differences were found in secondary outcomes.
conclusionWe were unable to detect any differences between the newborn wash product and water. These findings provide reassurance to parents who choose to use the test newborn wash product or other technically equivalent cleansers and provide the evidence for health care professionals to support parental choice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.