ArticleFrontiers in microbiology2013
Biochemistry of microbial itaconic acid production.
Article in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 181 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Synthesis and Characterization of Bioactive Oligoitaconates with Amino Acid Functional Groups for Tissue Engineering.International journal of molecular sciences · 2025Article
- Synthetic autotrophic yeast enables high itaconic acid production from COGreen chemistry : an international journal and green chemistry resource : GC · 2025Article
- Itaconic Anhydride as a Novel Bio-Derived Solid Electrolyte Interphase Forming Additive for Lithium-Ion Batteries.ChemSusChem · 2025Article
- Enhancing selective itaconic acid synthesis in Yarrowia lipolytica through targeted metabolite transport reprogramming.Biotechnology for biofuels and bioproducts · 2025Article
- Engineering of itaconic acid pathway via co-localization of CadA and AcnA in recombinant Escherichia coli.Biotechnology letters · 2024Article
- Efficient production of itaconic acid from the single-carbon substrate methanol with engineered Komagataella phaffii.Biotechnology for biofuels and bioproducts · 2024Article
- Exploitation of microbial activities at low pH to enhance planetary health.FEMS microbiology reviews · 2024Article
- A synthetic methylotrophicNature catalysis · 2024Article
- Effects of dimethyl itaconate on expressions of NGFI-A and NGFI-B and inflammatory cytokines in the spinal cord in the formalin test.Brain communications · 2024Article
- Statistical Optimization of Biosurfactant Production fromJournal of microbiology and biotechnology · 2023Article
- Free-Radical Propagation Rate Coefficients of Diethyl Itaconate and Di-n-Propyl Itaconate Obtained via PLP-SEC.Polymers · 2023Article
- Conversion of COProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Synergistic effects on itaconic acid production in engineered Aspergillus niger expressing the two distinct biosynthesis clusters from Aspergillus terreus and Ustilago maydis.Microbial cell factories · 2022Article
- Variation in Root Exudate Composition Influences Soil Microbiome Membership and Function.Applied and environmental microbiology · 2022Article
- Aconitic Acid Recovery from Renewable Feedstock and Review of Chemical and Biological Applications.Foods (Basel, Switzerland) · 2022Review
- The Effect of Different Soft Core/Hard Shell Ratios on the Coating Performance of Acrylic Copolymer Latexes.Polymers · 2021Article
- An integrated in vivo/in vitro framework to enhance cell-free biosynthesis with metabolically rewired yeast extracts.Nature communications · 2021Article
- TCA Cycle Replenishing Pathways in Photosynthetic Purple Non-Sulfur Bacteria Growing with Acetate.Life (Basel, Switzerland) · 2021Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Itaconic acid is an unsaturated dicarbonic acid which has a high potential as a biochemical building block, because it can be used as a monomer for the production of a plethora of products including resins, plastics, paints, and synthetic fibers. Some Aspergillus species, like A. itaconicus and A. terreus, show the ability to synthesize this organic acid and A. terreus can secrete significant amounts to the media (>80 g/L). However, compared with the citric acid production process (titers >200 g/L) the achieved titers are still low and the overall process is expensive because purified substrates are required for optimal productivity. Itaconate is formed by the enzymatic activity of a cis-aconitate decarboxylase (CadA) encoded by the cadA gene in A. terreus. Cloning of the cadA gene into the citric acid producing fungus A. niger showed that it is possible to produce itaconic acid also in a different host organism. This review will describe the current status and recent advances in the understanding of the molecular processes leading to the biotechnological production of itaconic acid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.