ArticleCellular oncology (Dordrecht, Netherlands)2013
ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.
Article in Cellular oncology (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis.Frontiers in oncology · 2021Pooled it
- A high expression ratio of RhoA/RhoB is associated with the migratory and invasive properties of basal-like Breast Tumors.International journal of medical sciences · 2020Article
- Novel Discoveries Targeting Pathogenic Gut Microbes and New Therapies in Pancreatic Cancer: Does Pathogenic E. coli Infection Cause Pancreatic Cancer Progression Modulated by TUBB/Rho/ROCK Signaling Pathway? A Bioinformatic Analysis.BioMed research international · 2020Article
- Moesin is an independent prognostic marker for ER-positive breast cancer.Oncology letters · 2019Article
- LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis.Molecular cancer · 2018Review
- Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cancer.BMC cancer · 2018Article
- Capable Infection of Hepatitis B Virus in Diffuse Large B-cell Lymphoma.Journal of Cancer · 2018Article
- Augmented expression of polo-like kinase 1 indicates poor clinical outcome for breast patients: a systematic review and meta-analysis.Oncotarget · 2017Review
- Phenotypic characterisation of breast cancer: the role of CDC42.Breast cancer research and treatment · 2017Article
- Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.Clinical & experimental metastasis · 2017Article
- Frequent alterations of SLIT2-ROBO1-CDC42 signalling pathway in breast cancer: clinicopathological correlation.Journal of genetics · 2016Article
- Augmented expression of Polo-like kinase 1 is a strong predictor of shorter cancer-specific overall survival in early stage breast cancer at 15-year follow-up.Oncology letters · 2016Article
- Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine.Scientific reports · 2016Article
- Article
- Specific upregulation of RHOA and RAC1 in cancer-associated fibroblasts found at primary tumor and lymph node metastatic sites in breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Chromosome 17 copy number changes in male breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2015Article
- Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes.Cellular oncology (Dordrecht, Netherlands) · 2015Article
- Critical functions of RhoB in support of glioblastoma tumorigenesis.Neuro-oncology · 2015Article
- BMP9 regulates cross-talk between breast cancer cells and bone marrow-derived mesenchymal stem cells.Cellular oncology (Dordrecht, Netherlands) · 2014Article
- Increase in ezrin expression from benign to malignant breast tumours.Cellular oncology (Dordrecht, Netherlands) · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to examine the expression of ERM (ezrin, moesin) and Rho (RhoA, RhoB and Cdc42) proteins in breast cancer (BC) patients and to investigate the relationship between the sub-cellular localisation of these proteins and clinicopathological characteristics and patient survival.
methodsThe expression and specific sub-cellular distribution of the ERM/Rho proteins was analysed by immunohistochemistry in a homogeneous group of 85 stage II ductal BC patients with a follow-up of 15 years.
resultsEnhanced immunoreactivity of all analysed proteins was found to be associated with the presence of lymph node metastases (ezrin, P = 0.047, moesin, P = 0.038, RhoA, P = 0.024, RhoB, P = 0.004 and Cdc42, P = 0.047). Nuclear localisation of ezrin was found to correlate with the presence of lymph nodes metastases (P = 0.004) and with histological de-differentiation (P = 0.015). In contrast, we found that the nuclear topography of RhoA and Cdc42, and the perinuclear localisation of RhoB, were strongly associated with a lack of nodal metastases (P = 0.008, P = 0.048, P = 0.001, respectively), whereas a decreased reactivity of RhoA in the stromal compartment of BC tumours was associated with the presence of lymph node metastases (P = 0.011). No relationship was observed between ERM/Rho protein expression and oestrogen receptor (ER), progesterone receptor (PgR) or HER-2 reactivity in the BC cells. Also, ERM/Rho protein expression did not predict patient survival, but RhoB over-expression in the stromal compartment of the tumours was found to be associated with a better prognosis (P = 0.0106).
conclusionsThe ERM/Rho immunoprofile and the assessment of its specific sub-cellular localisation may be instrumental for the prediction of lymph node metastases in ductal BC patients.
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