ArticlePolymer bulletin (Berlin, Germany)2013
Formulation of salicylate-based poly(anhydride-ester) microspheres for short- and long-term salicylic acid delivery.
Article in Polymer bulletin (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Rod-shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation.Advanced healthcare materials · 2025Article
- Polyanhydride Chemistry.Biomacromolecules · 2022Review
- Polysalicylic Acid Polymer Microparticle Decoys Therapeutically Treat Acute Respiratory Distress Syndrome.Advanced healthcare materials · 2022Article
- Poly(anhydride-ester) gemcitabine: Synthesis and particle engineering of a high payload hydrolysable polymeric drug for cancer therapy.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- Biodegradable salicylate-based poly(anhydride-ester) microspheres for controlled insulin delivery.Journal of biomedical materials research. Part A · 2014Article
- Pharmaceutical suspension containing both immediate/sustained-release amoxicillin-loaded gelatin nanoparticles: preparation and in vitro characterization.Drug design, development and therapy · 2013Article
- PolyMorphine: an innovative biodegradable polymer drug for extended pain relief.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The formulation of salicylate-based poly(anhydride-ester) (PAE) microspheres was optimized by altering polymer concentration and homogenization speed to improve the overall morphology. The microspheres were prepared using three salicylate-based PAEs with different chemical compositions comprised of either a heteroatomic, linear aliphatic, or branched aliphatic moiety. These PAEs broadened the range of complete salicylic acid release to now include days, weeks and months. The molecular weight (M(w)), polydispersity index (PDI) and glass transition temperature (T(g)) of the formulated polymers were compared to the unformulated polymers. In general, the M(w) and PDI exhibited decreased and increased values, respectively, after formulation, whereas the T(g) changes did not follow a specific trend. Microsphere size and morphology were determined using scanning electron microscopy. These microspheres exhibited smooth surfaces, no aggregation, and size distributions ranging from 2-34 m in diameter. In vitro release studies of the chemically incorporated salicylic acid displayed widely tunable release profiles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.