Evidence map›Paper›PMID 23420317›Full record

ArticleArchives of osteoporosis2013

A health economic analysis of osteoporotic fractures: who carries the burden?

Louise Hansen, Anne Sofie Mathiesen, Peter Vestergaard, Lars H Ehlers, Karin D Petersen

Registry-linked trialAbstract read
In one paragraph

Article in Archives of osteoporosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07056322 (Optimal Meals to Reduce Bone Resorption in Women With Osteopenia), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07056322 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Optimal Meals to Reduce Bone Resorption in Women With Osteopenia

TypeinterventionalSponsorUniversity of AarhusRan2025 to 2026Enrolled13ConditionsOsteopeniaArms200 ml dairy, 100 ml milk, 100 g banana, 100 ml dairy and fibers, Fasting (control)
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Socio-economic inequalities in fragility fracture incidence: a systematic review and meta-analysis of 61 observational studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  3. Pooled it
  4. Effectiveness of anti-osteoporotic drugs to prevent secondary fragility fractures: systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Pooled it
  5. Trial
  6. Trial
  7. When demography challenges policy: the rising burden of proximal femur fractures as a role model and driver for geriatric trauma care in Germany.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  8. Fracture trends in Denmark from 1997 to 2021.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  9. An enhanced Fracture Risk Evaluation Model (FREM) using national health data on morbidity and medications.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  10. Introducing FREMArchives of osteoporosis · 2025
    Article
  11. Article
  12. Healthcare and productivity cost of osteoporosis: a Danish register-based quasi-experimental study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  13. Article
  14. Impact of fragility fractures on activities of daily living and productivity in community-dwelling women: a multi-national study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
  15. Article
  16. Evaluating the performance of the Charlson Comorbidity Index (CCI) in fracture risk prediction and developing a new Charlson Fracture Index (CFI): a register-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  17. Article
  18. Article
  19. Aging and direct medical costs of osteoporotic fractures.Journal of bone and mineral metabolism · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Louise HansenDanish Center for Health Care Improvement, Aalborg University, Aalborg, Denmark. lhanse07@gmail.com
Anne Sofie Mathiesen
Peter Vestergaard
Lars H Ehlers
Karin D Petersen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThis is a cost-of-illness study of osteoporotic fractures in Denmark estimating the incremental societal cost associated with osteoporotic fractures, with both direct cost and productivity cost. This study includes cost regarding hospitals, general practices, the patients, the municipalities and regions. The total cost of osteoporotic fractures in Denmark was estimated at EUR 1.563 billion. PURPOSE: The aim of this study is to estimate the societal burden imposed by osteoporotic fractures in Denmark. In contrast to prior studies, this study will present a comprehensive model for the cost of osteoporotic fractures regarding hospitals, general practices, the municipalities, the regions and the patients.

methodsThis cost-of-illness study applied an incidence-based bottom-up approach from a societal perspective, including both direct costs and productivity costs. The study focused on incremental cost associated with osteoporotic fractures using a Markov model. Danish citizens ≥50 years with an osteoporotic fracture between 2001 and 2010 were studied.

resultsThe total cost of osteoporotic fractures in Denmark was estimated to EUR 1.563 billion in 2011, at EUR 628 million and EUR 936 million for men and women, respectively. The most expensive fracture for both genders was first hip fracture. The municipalities carried the majority of the costs, with 55-57 % of incremental lifetime cost.

conclusionsThis study showed that the incremental societal burden of osteoporotic fractures is an important health problem. Medical costs of the osteoporotic fractures were substantial cost for the health care sector, but were by far exceeded by the cost for the municipality in terms of social services and rehabilitation.

Indexed as

Cost of IllnessHealth Care CostsAgedDenmarkFemaleHumansMaleMiddle AgedOsteoporotic Fractures

Identifiers

PMID23420317
PMCPMC3880482

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.