ArticleBiomedical microdevices2013
A microfluidic immunomagnetic bead-based system for the rapid detection of influenza infections: from purified virus particles to clinical specimens.
Article in Biomedical microdevices, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Using Temporally and Spatially Resolved Measurements to Improve the Sensitivity of Fluorescence-Based Immunoassays.Biosensors · 2024Article
- Recent Advances in Rapid and Highly Sensitive Detection of Proteins and Specific DNA Sequences Using a Magnetic Modulation Biosensing System.Sensors (Basel, Switzerland) · 2022Review
- Optical modulation biosensing system for rapid detection of biological targets at low concentrations.Biomedical optics express · 2021Article
- On-Chip Optical Detection of Viruses: A Review.Advanced photonics research · 2021Article
- Rapid Enrichment and Ultrasensitive Detection of Influenza A Virus in Human Specimen using Magnetic Quantum Dot Nanobeads Based Test Strips.Sensors and actuators. B, Chemical · 2020Article
- A Cell-Based Capture Assay for Rapid Virus Detection.Viruses · 2020Article
- Simultaneous and automated detection of influenza A virus hemagglutinin H7 and H9 based on magnetism and size mediated microfluidic chip.Sensors and actuators. B, Chemical · 2020Article
- Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases.The Journal of infection · 2018Review
- Immunomagnetic separation of tumor initiating cells by screening two surface markers.Scientific reports · 2017Article
- A Stimuli-Responsive, Binary Reagent System for Rapid Isolation of Protein Biomarkers.Analytical chemistry · 2016Article
- Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays.Science advances · 2016Article
- Acoustofluidic Transfer of Inflammatory Cells from Human Sputum Samples.Analytical chemistry · 2016Article
- An acoustofluidic sputum liquefier.Lab on a chip · 2015Article
- Magnetic nanoparticle-based immunoassay for rapid detection of influenza infections by using an integrated microfluidic system.Nanomedicine : nanotechnology, biology, and medicine · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Seasonal and novel influenza infections have the potential to cause worldwide pandemics. In order to properly treat infected patients and to limit its spread, a rapid, accurate and automatic influenza diagnostic tool needs to be developed. This study therefore presents a new integrated microfluidic system for the rapid detection of influenza infections. It integrated a suction-type, pneumatic-driven microfluidic control module, a magnetic bead-based fluorescent immunoassay (FIA) and an end-point optical detection module. This new system can successfully distinguish between influenza A and B using a single chip test within 15 min automatically, which is faster than existing devices. By utilizing the micromixers to thoroughly wash out the sputum-like mucus, this microfluidic system could be used for the diagnosis of clinical specimens and reduced the required sample volume to 40 μL. Furthermore, the results of diagnostic assays from 86 patient specimens have demonstrated that this system has 84.8 % sensitivity and 75.0 % specificity. This developed system may provide a powerful platform for the fast screening of influenza infections.
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