ArticleHeart failure reviews2013
Viral genomes in the pericardial fluid and in peri- and epicardial biopsies from a German cohort of patients with large to moderate pericardial effusions.
Article in Heart failure reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Guideline
- Guideline
- Pericardial effusion as a potential site of localized DNA virus reactivation following U-CB transplantation.International journal of hematology · 2025Article
- Etiologies, fluid characteristics, and outcomes of pericardiocentesis: a five-year retrospective study from a single center.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- Acute idiopathic pericarditis during a national lockdown to prevent transmission of SARS-COVID-19.International journal of cardiology. Heart & vasculature · 2024Article
- Interleukin-1 Blockers: A Paradigm Shift in the Treatment of Recurrent Pericarditis.Life (Basel, Switzerland) · 2024Review
- Fibrous Pericardial Mass Signifying the Importance of Advanced Cardiovascular Imaging: A Case Report.International medical case reports journal · 2024Article
- Article
- US Database Study of Clinical Burden and Unmet Need in Recurrent Pericarditis.Journal of the American Heart Association · 2021Article
- Epstein-Barr Virus DNA in Pericardial Effusion Causing Subacute Cardiac Tamponade.CASE (Philadelphia, Pa.) · 2021Article
- Idiopathic Pericarditis-an Autoinflammatory Disease?Current rheumatology reports · 2019Review
- Article
- Human Parvoviruses.Clinical microbiology reviews · 2017Review
- Recurrent Pericarditis: Modern Approach in 2016.Current cardiology reports · 2016Review
- Article
- Article
- Article
- Immortalization protocols used in cell culture models of human breast morphogenesis.Cellular and molecular life sciences : CMLS · 2004Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aetiology of pericardial effusion has been generally assessed by clinical work-up only, which leaves a large cohort of patients with "idiopathic" effusions virtually undiagnosed. In accordance with the ESC guidelines, this contribution intends to change this attitude. After therapeutic or diagnostic pericardiocentesis of 259 patients with large to moderate pericardial effusions, pericardial fluid, epicardial and pericardial biopsies, and blood samples were analysed by PCR for cardiotropic microbial agents. Cytology, histology, immunohistology of tissue and fluids and laboratory tests were performed. Of the 259 patients, 35 % suffered from an autoreactive aetiology, 28 % suffered from a malignant and 14 % from an infectious cause. Investigating all samples by PCR, we identified viral genomes in 51 (19.7 %) patients, parvovirus B19 (B19 V) being identified in 25 and Epstein-Barr virus (EBV) in 19 cases. In patients with a sole infectious aetiology (n = 36), B19 V was detected in 21 and EBV in 10 cases. When differentiating with regard to the material investigated for the presence of cardiotropic viruses, parvovirus B19 was most often detected in the epicardium and EBV was most frequently detected in the pericardial fluid independent from the final diagnostic categorisation. Bacterial cultures including tests for tuberculosis were all negative. Molecular techniques improve sensitivity, specificity and diagnostic accuracy for the underlying aetiology in pericarditis patients with effusion. The identification of specific viral signatures will help to understand pathogenetic mechanisms in pericarditis and allow to tailor an adequate therapy beyond antiphlogistic treatment.
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