ArticleNature reviews. Cardiology2013
Diabetes: Looking back at Look AHEAD--giving lifestyle a chance.
Article in Nature reviews. Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: A systematic review and meta-analysis.The international journal of behavioral nutrition and physical activity · 2017Pooled it
- Effect of a Weight Loss and Lifestyle Intervention on Dietary Behavior in Men with Obstructive Sleep Apnea: The INTERAPNEA Trial.Nutrients · 2022Trial
- Enhanced motivational interviewing for reducing weight and increasing physical activity in adults with high cardiovascular risk: the MOVE IT three-arm RCT.Health technology assessment (Winchester, England) · 2019Trial
- Intensive lifestyle intervention reduces urinary incontinence in overweight/obese men with type 2 diabetes: results from the Look AHEAD trial.The Journal of urology · 2014Trial
- The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience.Diabetes care · 2026Review
- Changes in behaviors after diagnosis of type 2 diabetes and 10-year incidence of cardiovascular disease and mortality.Cardiovascular diabetology · 2019Article
- Diet and exercise in the management of obstructive sleep apnoea and cardiovascular disease risk.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Association of Comorbid and Metabolic Factors with Optimal Control of Type 2 Diabetes Mellitus.North American journal of medical sciences · 2016Article
- Look inside Look AHEAD: why the glass is more than half-full.Current diabetes reports · 2014Review
- Role of bariatric surgery in diabetes.Current cardiology reports · 2014Review
- Diabetes: Look AHEAD published: weight loss not linked to fewer cardiovascular events in patients with type 2 diabetes.Nature reviews. Endocrinology · 2013Article
- Diabetes: Look AHEAD published: weight loss not linked to fewer cardiovascular events in patients with type 2 diabetes.Nature reviews. Cardiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Look AHEAD trial did not show that a lifestyle modification programme aimed at weight loss could reduce the incidence of cardiovascular disease events. We attempt to address why this trial was 'negative', and emphasize that further randomized trials of lifestyle modification focusing on the effects of physical activity and exercise are needed.
Indexed as
Identifiers
23419903What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.