ReviewBrain research2013
Factors influencing the cognitive and neural effects of hormone treatment during aging in a rodent model.
Review in Brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Changes in sex differences in neuroanatomical structure and cognitive behavior across the life span.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Effects of Radix Polygalae on Cognitive Decline and Depression in Estradiol Depletion Mouse Model of Menopause.Current issues in molecular biology · 2021Article
- The Role of Estrogen in Anxiety-Like Behavior and Memory of Middle-Aged Female Rats.Frontiers in endocrinology · 2020Article
- Effects of Cyclophosphamide and/or Doxorubicin in a Murine Model of Postchemotherapy Cognitive Impairment.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Socially Housed Female Macaques: a Translational Model for the Interaction of Chronic Stress and Estrogen in Aging.Current psychiatry reports · 2017Review
- Evaluating the Role of Hormone Therapy in Postmenopausal Women with Alzheimer's Disease.Drugs & aging · 2016Review
- Benefits of Hormone Therapy Estrogens Depend on Estrogen Type: 17β-Estradiol and Conjugated Equine Estrogens Have Differential Effects on Cognitive, Anxiety-Like, and Depressive-Like Behaviors and Increase Tryptophan Hydroxylase-2 mRNA Levels in Dorsal Raphe Nucleus Subregions.Frontiers in neuroscience · 2016Article
- Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease.Experimental and therapeutic medicine · 2016Article
- Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it?Hormones and behavior · 2015Article
- Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats.Hormones and behavior · 2013Article
- The effects of dietary treatment with S-equol on learning and memory processes in middle-aged ovariectomized rats.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Whether hormone treatment alters brain structure or has beneficial effects on cognition during aging has recently become a topic of debate. Although previous research has indicated that hormone treatment benefits memory in menopausal women, several newer studies have shown no effect or detrimental effects. These inconsistencies emphasize the need to evaluate the role of hormones in protecting against age-related cognitive decline in an animal model. Importantly, many studies investigating the effects of estrogen and progesterone on cognition and related brain regions have used young adult animals, which respond differently than aged animals. However, when only the studies that have examined the effects of hormone treatment in an aging model are reviewed, there are still varied behavioral and neural outcomes. This article reviews some of the important factors that can influence the behavioral and neural outcomes of hormone treatment including the type of estrogen administered, whether or not estrogen is combined with progesterone and if so, the type of progesterone used, as well as the route, mode, and length of treatment. How these factors influence cognitive outcomes highlights the importance of study design and avoiding generalizations from a small number of studies. This article is part of a Special Issue entitled Hormone Therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.