SynthesisNeurotoxicology2013
The neurobehavioral impact of manganese: results and challenges obtained by a meta-analysis of individual participant data.
Synthesis in Neurotoxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- Effects of mixed metal exposures on MRI diffusion features in the medial temporal lobe.Neurotoxicology · 2024Article
- Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.Environmental health perspectives · 2024Article
- Effects of mixed metal exposures on MRI diffusion features in the medial temporal lobe.medRxiv : the preprint server for health sciences · 2024Article
- Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy.Metabolic brain disease · 2023Article
- Higher hippocampal diffusivity values in welders are associated with greater R2* in the red nucleus and lower psychomotor performance.Neurotoxicology · 2023Article
- Joint Effect of Multiple Metals on Hyperuricemia and Their Interaction with Obesity: A Community-Based Cross-Sectional Study in China.Nutrients · 2023Article
- Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.International journal of molecular sciences · 2022Review
- Protective effect of calpain inhibitors against manganese-induced toxicity in rats.Metabolic brain disease · 2022Article
- Neuropsychological function among workers exposed to aluminum - a mini-review.Industrial health · 2022Review
- Exposure to Mild Steel Welding and Changes in Serum Proteins With Putative Neurological Function-A Longitudinal Study.Frontiers in public health · 2020Article
- The effects of occupational exposure to manganese fume on neurobehavioral and neurocognitive functions: An analytical cross-sectional study among welders.EXCLI journal · 2020Article
- Role of Astrocytes in Manganese Neurotoxicity Revisited.Neurochemical research · 2019Review
- Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease.International archives of occupational and environmental health · 2019Article
- Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior.Environment international · 2018Article
- Welding-related brain and functional changes in welders with chronic and low-level exposure.Neurotoxicology · 2018Article
- Toenail Manganese: A Sensitive and Specific Biomarker of Exposure to Manganese in Career Welders.Annals of work exposures and health · 2017Article
- Assessing human metal accumulations in an urban superfund site.Environmental toxicology and pharmacology · 2017Article
- Environmental exposure to manganese in air: Associations with tremor and motor function.The Science of the total environment · 2016Article
- Manganese Exposure and Neurocognitive Outcomes in Rural School-Age Children: The Communities Actively Researching Exposure Study (Ohio, USA).Environmental health perspectives · 2015Article
Corrections and comments
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Authors and funding
21 authors at 14 institutions in 8 countries.
Funding
Abstract
Results from a meta-analysis of aggregated data provoked a new analysis using individual data on the neuropsychological performance of occupationally exposed workers. Data from eight studies examining 579 exposed and 433 reference participants were included, 28 performance variables analyzed. The performance scores were adjusted for well-known individual-level covariates; the influence of possible, but unknown study-level covariates was attenuated by means of a z-normalization. Associations between performance and exposure were estimated by ANOVAs and ANCOVAs, the latter representing multi-level models. Four cognitive and motor performance variables each indicated significantly lower performances of exposed individuals when confounding was considered; slowed motor performances and deficits in attention and short-term memory were found. Performance on a single test was significantly related to the biomarker manganese in blood. The outcomes on susceptibility were weak. The slowing of responses was the most distinct feature of performances of exposed workers. It remains unclear, whether this result is related to the employed tests or provides important information about early stages of the neurotoxic impairment. More specific cognitive tests need to be employed to answer this question. The lack of dose-response relationships was related to features of the biomarker: it does not reflect the Mn in brain responsible for changes in performances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.