ReviewActa veterinaria Scandinavica2013
Coxiella burnetii associated reproductive disorders in domestic animals--a critical review.
Review in Acta veterinaria Scandinavica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 3 syntheses or guidelines pooled it, 271 citations in OpenAlex.
- Global and regional seroprevalence of coxiellosis in small ruminants: A systematic review and meta-analysis.Veterinary medicine and science · 2024Pooled it
- Global prevalence and species diversity of tick-borne pathogens in buffaloes worldwide: a systematic review and meta-analysis.Parasites & vectors · 2023Pooled it
- Bovine infectious abortion: a systematic review and meta-analysis.Frontiers in veterinary science · 2023Pooled it
- Seroprevalence of Q-fever among domestic ruminants, humans and ticks in Ethiopia: A systematic review and meta-analysis.Veterinary and animal science · 2026Review
- High Seropositivity toAnimals : an open access journal from MDPI · 2026Article
- Q Fever in Africa: A Systematic Review of Prevalence, Zoonotic Potential and Disease Burden.Public health challenges · 2026Review
- Article
- Vector-borne diseases-knowledge maps.EFSA journal. European Food Safety Authority · 2026Article
- Seroprevalence of Q fever among humans and animals in East Africa: a systematic review and meta-analysis.One health outlook · 2026Review
- Molecular and Serological Detection of Coxiella burnetii in Small Ruminants in Northeastern Brazil.Veterinary medicine and science · 2026Article
- Investigation of Coxiella burnetii distribution in a Scottish dairy cattle herd with history of stillbirths.The Veterinary record · 2026Article
- TFEB and MCOLN1 are important forFrontiers in cellular and infection microbiology · 2026Article
- Impact of whole-herd vaccination on a caprine coxiellosis outbreak: a longitudinal study ofFrontiers in microbiology · 2026Article
- Sero-epidemiology of Coxiella burnetii in livestock and humans in Isiolo county Kenya.PLoS neglected tropical diseases · 2025Article
- National serosurvey and risk mapping reveal widespread distribution of Coxiella burnetii in Kenya.Scientific reports · 2025Article
- Molecular detection of Chlamydiales organisms in ruminant abortions in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Detection ofFoods (Basel, Switzerland) · 2025Article
- Detection of abortifacient agents in domestic ruminants, with a specific focus onOpen research Europe · 2025Article
- Article
- Risk factors influencing Coxiella burnetii seropositivity in water Buffalo (Bubalus bubalis) populations of Egypt's Nile Delta.PloS one · 2025Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterium Coxiella burnetii has been detected in the fetal membranes, birth fluids and vaginal mucus, as well as in the milk and other excretions of several domestic mammals. The finding of C. burnetii in association with abortion, parturition and in the postpartum period has led to the hypothesis that C. burnetii causes a range of reproductive diseases. This review critically evaluates the scientific basis for this hypothesis in domestic mammals.The review demonstrates a solid evidence for the association between C. burnetii infection and sporadic cases of abortion, premature delivery, stillbirth and weak offspring in cattle, sheep and goats. C. burnetii induced in-herd epidemics of this complete expression of reproductive failure have been reported for sheep and goats, but not for cattle. The single entities occur only as part of the complex and not as single events such as generally increased stillbirth rate. Studies show that C. burnetii initially infects the placenta and that subsequent spread to the fetus may occur either haematogenous or by the amniotic-oral route. The consequences for the equine, porcine, canine and feline conceptus remains to the elucidated but that infection of the conceptus may occur is documented for most species. There is no solid evidence to support a hypothesis of C. burnetii causing disorders such as subfertility, endometritis/metritis, or retained fetal membranes in any kind of domestic animal species.There is a strong need to validate non-pathology based methods such as polymerase chain reaction for their use in diagnostic and research in relation to establishing C. burnetii as the cause of abortion and to adapt an appropriate study design and include adequate control animals when linking epidemiological findings to C. burnetii or when evaluating effects of vaccination in production herds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.