Evidence map›Paper›PMID 23419177›Full record

ArticleJournal of the American Chemical Society2013

Synthesis of nanostructured and biofunctionalized water-in-oil droplets as tools for homing T cells.

Ilia Platzman, Jan-Willi Janiesch, Joachim Pius Spatz

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. A Robust Synthesis of Fluorosurfactants with Tunable Functionalities via a Two-Step Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Segregation of Dispersed Silica Nanoparticles in Microfluidic Water-in-Oil Droplets: A Kinetic Study.Chemphyschem : a European journal of chemical physics and physical chemistry · 2020
    Article
  11. Article
  12. Article
  13. Reconstitution and Coupling of DNA Replication and Segregation in a Biomimetic System.Chembiochem : a European journal of chemical biology · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. T cell immunoengineering with advanced biomaterials.Integrative biology : quantitative biosciences from nano to macro · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ilia PlatzmanDepartment of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, 70569 Stuttgart, Germany.
Jan-Willi Janiesch
Joachim Pius Spatz

Funding

Nanomedicine development center for mechanobiologyPN2EY016586 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2005 to 2014
$23.0M
NEI NIH HHS PN2 EY016586
6 · The paper itself

Abstract

Activation, ex vivo expansion of T cells, differentiation into a regulatory subset, and its phenotype-specific high-throughput selection represent major challenges in immunobiology. In part, this is due to the lack of technical means to synthesize suitable 3D extracellular systems to imitate ex vivo the cellular interactions between T cells and antigen-presenting cells (APCs). In this study, we synthesized a new type of gold-linked surfactant and used a drop-based microfluidic device to develop and characterize novel nanostructured and specifically biofunctionalized droplets of water-in-oil emulsions as 3D APC analogues. Combining flexible biofunctionalization with the pliable physical properties of the nanostructured droplets provided this system with superior properties in comparison with previously reported synthetic APC analogues.

Indexed as

Antigen-Presenting CellsGoldMetal NanoparticlesMicrofluidic Analytical TechniquesOilsParticle SizeSurface-Active AgentsSurface PropertiesT-LymphocytesWaterGoldOilsSurface-Active AgentsWater

Identifiers

PMID23419177
PMCPMC3806295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.