ArticleAnalytical chemistry2013
Photonic crystal lab-on-a-chip for detecting staphylococcal enterotoxin B at low attomolar concentration.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Single-Molecule Monitoring of Nucleic Acid Dynamics Using Raman Correlation Spectroscopy in Plasmonic Nanowells.ACS nano · 2025Article
- Integrated Photonic Biosensors: Enabling Next-Generation Lab-on-a-Chip Platforms.Nanomaterials (Basel, Switzerland) · 2025Review
- Mesoporous Silica Nanoparticles-Enhanced Microarray Technology for Highly Sensitive Simultaneous Detection of Multiplex Foodborne Pathogens.ACS applied bio materials · 2024Article
- Ultrasensitive detection of Staphylococcal enterotoxin B in milk based on target-triggered assembly of the flower like nucleic acid nanostructure.RSC advances · 2019Article
- Chronocoulometric aptamer based assay for staphylococcal enterotoxin B by target-triggered assembly of nanostructured dendritic nucleic acids on a gold electrode.Mikrochimica acta · 2019Article
- Enrichment and immobilization of macromolecular analytes on a porous membrane utilizing permeation drag.Journal of pharmaceutical analysis · 2018Article
- Photonic crystals: emerging biosensors and their promise for point-of-care applications.Chemical Society reviews · 2017Review
- A novel IgY-Aptamer hybrid system for cost-effective detection of SEB and its evaluation on food and clinical samples.Scientific reports · 2015Article
- Fluorescence-based bioassays for the detection and evaluation of food materials.Sensors (Basel, Switzerland) · 2015Review
- FRET-based homogeneous immunoassay on a nanoparticle-based photonic crystal.Analytical and bioanalytical chemistry · 2015Article
- Relative efficiency of zinc sulfide (ZnS) quantum dots (QDs) based electrochemical and fluorescence immunoassay for the detection ofBiotechnology reports (Amsterdam, Netherlands) · 2015Article
- Two-dimensional photonic crystals for sensitive microscale chemical and biochemical sensing.Lab on a chip · 2015Review
- Development of an ELISA microarray assay for the sensitive and simultaneous detection of ten biodefense toxins.The Analyst · 2014Article
- On-chip detection of a single nucleotide polymorphism without polymerase amplification.Nano research · 2014Article
- Isolation and epitope mapping of staphylococcal enterotoxin B single-domain antibodies.Sensors (Basel, Switzerland) · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Nanoscale wells have been fabricated in a chip to construct a photonic crystal that is used for enhanced immunoassays of a common food-borne toxin, Staphylococcal enterotoxin B (SEB). The nanostructure of the photonic crystal (PC) in the array enhanced the fluorescent signal due to a guided mode resonance. Nanoparticles were used as the solid substrate for attachment of capture antibodies; the particles were then isolated in individual wells of the chip by using an electrophoretic particle entrapment system (EPES). The standard curve generated from the chip consisted of two log-linear regions: the first region with a greater sensitivity, limited by the Kd of the antibody, resembling the 96-well plate ELISA and the other that shows greater than six orders of linearity extending to attomolar concentrations, which is unique to the device we have developed. SEB dissolved in phosphate buffered saline was resolved to levels as low as 35 aM with 10(6)-fold better limit of detection than a conventional 96-well-ELISA. Different concentrations of SEB spiked into milk were tested to assess the reliability of the device and the efficacy of the extended log-linear regime in a "real" food matrix. The presence of the milk did not significantly alter the limit of detection. With very low amounts of sample (less than 10 μL) and fast read-out time, the PC-based system shows great promise for the detection of a wide range of target molecules with close to a single molecule level of sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.