ArticleBMC research notes2013
Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size in Y-consomic strains.
Article in BMC research notes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines.Ecology and evolution · 2019Article
- Quantitative trait loci that control body weight in DDD/Sgn and C57BL/6J inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Chromosome Y genetic variants: impact in animal models and on human disease.Physiological genomics · 2015Review
- Effect of the Y chromosome on testis weight in mice.The Journal of veterinary medical science · 2015Article
- Y genetic variation and phenotypic diversity in health and disease.Biology of sex differences · 2015Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have established 17 Y chromosome consomic (Y-consomic) mouse strains in an inbred DH/Sgn strain. In this study, based on investigations in four different genetic backgrounds, we proved that the Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size.
findingsIn the DH-Chr Y-+/+ background, Y chromosome substitution significantly decreased the body weight in DH-Chr Y(KK)-+/+ and DH-Chr Y(SJL)-+/+ strains, and the DH-Chr Y(KK)-+/+ strain was the lightest among the 17 Y-consomic strains. In the DH-Chr Y-Dh/+ background (Dh/+ mice have skeletal malformations and are usually lighter than +/+ mice), although Y chromosome substitution did not significantly alter the body weight, the DH-Chr Y(KK)-Dh/+ strain was the lightest among the 17 Y-consomic-Dh/+ strains. In the (B6.Cg-A(y) × DH-Chr Y) F1-+/+ background, Y chromosome substitution significantly decreased the body weight and length in the (B6.Cg-A(y) × DH-Chr Y(KK)) F1 hybrids. In the (B6.Cg-A(y) × DH-Chr Y) F1-A(y)/+ background (Ay causes obesity and promotes linear growth), Y chromosome substitution significantly decreased body weight and length in the (B6.Cg-A(y) × DH-Chr Y(KK)) F1-A(y)/+ hybrids.
conclusionA body-size-reducing effect of the Y chromosome of the KK/Ta mouse strain was observed irrespective of genetic background. The effect was observed in the presence of Dh and A(y), the autosomal dominant mutations, both of which are known to have substantial effects on body size. These results suggest that there are Y-linked genes that control the body size in mice.
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