Trial reportInternational wound journal2015
Hyperhomocysteinaemia and chronic venous ulcers.
Trial report in International wound journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Doxycycline speeds up healing of chronic venous ulcers.International wound journal · 2015Trial
- Low molecular weight heparin improves healing of chronic venous ulcers especially in the elderly.International wound journal · 2015Trial
- Aterofisiol(®) in carotid plaque evolution.Drug design, development and therapy · 2015Trial
- The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs.Drug design, development and therapy · 2014Trial
- The Impact of Nutritional Condition and Compression Treatment on Venous Ulcer Recovery: A Systematic Review.Cureus · 2024Review
- Effects of Oral Nutritional Supplementation on Patients with Venous Ulcers: A Clinical Trial.Journal of clinical medicine · 2022Article
- Homocysteine and Inflammatory Cytokines in the Clinical Assessment of Infection in Venous Leg Ulcers.Antibiotics (Basel, Switzerland) · 2022Article
- Complex treatment of venous leg ulcers including the use of oral nutritional supplementation: results of 12-week prospective study.Postepy dermatologii i alergologii · 2022Article
- Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person.The EPMA journal · 2021Review
- Precision Medicine and Precision Nursing: The Era of Biomarkers and Precision Health.International journal of general medicine · 2020Review
- PredyCLU: a prediction system for chronic leg ulcers based on fuzzy logic; part I - exploring the venous side.International wound journal · 2016Article
- Study on the efficacy of surgery of the superficial venous system and of compression therapy at early stages of chronic venous disease for the prevention of chronic venous ulceration.International wound journal · 2016Article
- Effectiveness of prostaglandin E1 in patients with mixed arterial and venous ulcers of the lower limbs.International wound journal · 2016Article
- The use of growth factors, CD34(+) cells and fibrin for the management of chronic venous ulcers.International wound journal · 2016Article
- Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study.International wound journal · 2016Article
- Effects of a new nutraceutical substance on clinical and molecular parameters in patients with chronic venous ulceration.International wound journal · 2016Article
- Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines.International wound journal · 2016Article
- The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation.Journal of diabetes research · 2016Review
- Role of matrix metalloproteinases in non-healing venous ulcers.International wound journal · 2015Article
- A late diagnosis of hyperhomocysteinemia with probable evolution to verrucous elephantiasis nostra and leg ulcers.Anais brasileiros de dermatologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic venous ulceration (CVU) is the major cause of chronic wounds of lower extremities, and is a part of the complex of chronic venous disease. Previous studies have hypothesised that several thrombophilic factors, such as hyperhomocysteinaemia (HHcy), may be associated with chronic venous ulcers. In this study, we evaluated the prevalence of HHcy in patients with venous leg ulcers and the effect of folic acid therapy on wound healing. Eighty-seven patients with venous leg ulcers were enrolled in this study to calculate the prevalence of HHcy in this population. All patients underwent basic treatment for venous ulcer (compression therapy ± surgical procedures). Patients with HHcy (group A) received basic treatment and administered folic acid (1·2 mg/day for 12 months) and patients without HHcy (group B) received only basic treatment. Healing was assessed by means of computerised planimetry analysis. The prevalence of HHcy among patients with chronic venous ulcer enrolled in this study was 62·06%. Healing rate was significantly higher (P < 0·05) in group A patients (78·75%) compared with group B patients (63·33%). This study suggests a close association, statistically significant, between HHcy and CVU. Homocysteine-lowering therapy with folic acid seems to expedite wound healing. Despite these aspects, the exact molecular mechanisms between homocysteine and CVU have not been clearly defined and further studies are needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.