ArticleTranslational oncology2013
Three-Dimensional Telomeric Analysis of Isolated Circulating Tumor Cells (CTCs) Defines CTC Subpopulations.
Article in Translational oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Circulating tumour cells as a window into lethality in prostate cancer.Nature reviews. Urology · 2026Review
- CTC-5: A novel digital pathology approach to characterise circulating tumour cell biodiversity.Heliyon · 2023Article
- Telomere-Associated Changes in Nuclear Architecture of Cancer-Associated Macrophage-like Cells in Liquid Biopsies from Melanoma Patients.Biomedicines · 2022Article
- Blood-Derived Biomarkers of Diagnosis, Prognosis and Therapy Response in Prostate Cancer Patients.Journal of personalized medicine · 2021Review
- Genomic Instability in Circulating Tumor Cells.Cancers · 2020Review
- Genomic Analysis of Localized High-Risk Prostate Cancer Circulating Tumor Cells at the Single-Cell Level.Cells · 2020Article
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- Evaluation of the liquid biopsy for the detection of BRAFV600E mutation in metastatic melanoma patients.Cancer biomarkers : section A of Disease markers · 2019Article
- Circulating Tumor Cells (CTC) and Cell-Free DNA (cfDNA) Workshop 2016: Scientific Opportunities and Logistics for Cancer Clinical Trial Incorporation.International journal of molecular sciences · 2016Article
- Challenges in circulating tumor cell detection by the CellSearch system.Molecular oncology · 2016Review
- Circulating tumor cell isolation: the assets of filtration methods with polycarbonate track-etched filters.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2015Review
- Using circulating tumor cells to inform on prostate cancer biology and clinical utility.Critical reviews in clinical laboratory sciences · 2015Review
- Pathways and therapeutic targets in melanoma.Oncotarget · 2014Review
- Biosensors for the detection of circulating tumour cells.Sensors (Basel, Switzerland) · 2014Review
- Circulating Tumor Cell Detection and Capture by Photoacoustic Flow Cytometry in Vivo and ex Vivo.Cancers · 2013Article
- Three-dimensional Nuclear Telomere Organization in Multiple Myeloma.Translational oncology · 2013Article
- Are morphological criteria sufficient for the identification of circulating tumor cells in renal cancer?Journal of translational medicine · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating tumor cells (CTCs) have been identified with the potential to serve as suitable biomarkers for tumor stage and progression, but the availability of effective isolation technique(s) coupled with detailed molecular characterization have been the challenges encountered in making CTCs clinically relevant. For the first time, we combined isolation of CTCs using the ScreenCell filtration technique with quantitative analysis of CTC telomeres by TeloView. This resulted in the identification and molecular characterization of different subpopulations of CTCs in the same patient. Three-dimensional (3D) telomeric analysis was carried out on isolated CTCs of 19 patients that consisted of four different tumor types, namely, prostate, colon, breast, melanoma, and one lung cancer cell line. With telomeric analysis of the filter-isolated CTCs, the level of chromosomal instability (CIN) of the CTCs can be determined. Our study shows that subpopulations of CTCs can be identified on the basis of their 3D telomeric properties.
Identifiers
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Registered trials
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