Trial reportPloS one2013
Sleep debt elicits negative emotional reaction through diminished amygdala-anterior cingulate functional connectivity.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed, 4 syntheses or guidelines pooled it, 222 citations in OpenAlex.
- Preferential consolidation of emotional reactivity during sleep: A systematic review and meta-analysis.Frontiers in behavioral neuroscience · 2022Pooled it
- Pooled it
- Sleep Problems and Workplace Violence: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI.Neuroscience and biobehavioral reviews · 2017Pooled it
- Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Sleep, rest-activity rhythm, cognitive and emotional symptoms in adult ADHD: unraveling the links with an actimetry-based approach.BMC psychiatry · 2026Trial
- Trial
- Adaptive light: a lighting control method aligned with dark adaptation of human vision.Scientific reports · 2020Trial
- Trial
- Feedback Blunting: Total Sleep Deprivation Impairs Decision Making that Requires Updating Based on Feedback.Sleep · 2015Trial
- Correlates of polysomnographic sleep changes in cocaine dependence: self-administration and clinical outcomes.Drug and alcohol dependence · 2014Trial
- Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.PloS one · 2014Trial
- Trait anxiety selectively amplifies reward learning under uncertainty, while N3 sleep attenuates it.iScience · 2026Article
- Longitudinal association of nonrestorative sleep with subjective health and work performance: a cohort study in the Japanese construction industry.Industrial health · 2026Article
- Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety.International journal of molecular sciences · 2026Review
- Ketogenic diet for pediatric drug-resistant epilepsy: sleep, children's psychosocial functioning, and maternal mental health.Pediatric research · 2026Article
- Association between nonrestorative sleep and increased healthcare costs: a 6-year cohort study.Sleep and biological rhythms · 2026Article
- Partial sleep deprivation with a 2-h time-in-bed may not change divergent thinking and insight problem solving in young males: a Bayesian analysis.Journal of physiological anthropology · 2026Article
- Beyond Suicidal Ideation: Identifying High-Risk University Students Through Depression, Sleep Disturbance, and Impulsivity-A Cross-Sectional Secondary Analysis.Journal of clinical medicine · 2026Article
- Sleep disturbance is associated with greater subjective and neural negative emotionality in people with alcohol use disorder.Drug and alcohol dependence · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSleep debt reportedly increases emotional instability, such as anxiety and confusion, in addition to sleepiness and psychomotor impairment. However, the neural basis of emotional instability due to sleep debt has yet to be elucidated. This study investigated changes in emotional responses that are elicited by the simulation of short-term sleep loss and the brain regions responsible for these changes. SUBJECTS AND
methodsFourteen healthy adult men aged 24.1±3.3 years (range, 20-32 years) participated in a within-subject crossover study consisting of 5-day sessions of both sleep debt (4 h for time in bed) and sleep control (8 h for time in bed). On the last day of each session, participants underwent polysomnography and completed the State-Trait Anxiety Inventory and Profile of Mood States questionnaires. In addition, functional magnetic resonance imaging was conducted while performing an emotional face viewing task.
resultsRestricted sleep over the 5-day period increased the activity of the left amygdala in response to the facial expression of fear, whereas a happy facial expression did not change the activity. Restricted sleep also resulted in a significant decrease in the functional connectivity between the amygdala and the ventral anterior cingulate cortex (vACC) in proportion to the degree of sleep debt (as indicated by the percentage of slow wave sleep and δ wave power). This decrease was significantly correlated with activation of the left amygdala and deterioration of subjective mood state.
conclusionThe results of this study suggest that continuous and accumulating sleep debt that can be experienced in everyday life can downregulate the functional suppression of the amygdala by the vACC and consequently enhance the response of the amygdala to negative emotional stimuli. Such functional alteration in emotional control may, in part, be attributed to the neural basis of emotional instability during sleep debt.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.