ArticlePloS one2013
Identification of a Drosophila glucose receptor using Ca2+ imaging of single chemosensory neurons.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Bitter Sensing ProtectsThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Molecular Functions and Physiological Roles of Gustatory Receptors of the SilkwormInternational journal of molecular sciences · 2024Review
- Evolution of chemosensory tissues and cells across ecologically diverse Drosophilids.Nature communications · 2024Article
- Molecular sensors in the taste system of Drosophila.Genes & genomics · 2023Review
- Adaptation ofeLife · 2022Article
- The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila.PLoS biology · 2022Article
- A functional division ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Which Sugar to Take and How Much to Take? Two Distinct Decisions Mediated by Separate Sensory Channels.Frontiers in molecular neuroscience · 2022Article
- Mechanisms of Carboxylic Acid Attraction inMolecules and cells · 2021Article
- Taste recognition through tarsal gustatory sensilla potentially important for host selection in leaf beetles (Coleoptera: Chrysomelidae).Scientific reports · 2020Article
- Recent advances in the genetic basis of taste detection in Drosophila.Cellular and molecular life sciences : CMLS · 2020Review
- Identification and functional characterization of D-fructose receptor in an egg parasitoid, Trichogramma chilonis.PloS one · 2019Article
- Transcriptomics reveal the molecular underpinnings of chemosensory proteins in Chlorops oryzae.BMC genomics · 2018Article
- Internal amino acid state modulates yeast taste neurons to support protein homeostasis ineLife · 2018Article
- Molecular basis of fatty acid taste ineLife · 2017Article
- A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste.PLoS genetics · 2017Article
- Ionotropic Receptors Mediate Drosophila Oviposition Preference through Sour Gustatory Receptor Neurons.Current biology : CB · 2017Article
- Chemosensory gene expression in olfactory organs of the anthropophilic Anopheles coluzzii and zoophilic Anopheles quadriannulatus.BMC genomics · 2017Article
- Antennal transcriptome and expression analyses of olfactory genes in the sweetpotato weevil Cylas formicarius.Scientific reports · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Evaluation of food compounds by chemosensory cells is essential for animals to make appropriate feeding decisions. In the fruit fly Drosophila melanogaster, structurally diverse chemicals are detected by multimeric receptors composed of members of a large family of Gustatory receptor (Gr) proteins. Putative sugar and bitter receptors are expressed in distinct subsets of Gustatory Receptor Neurons (GRN) of taste sensilla, thereby assigning distinct taste qualities to sugars and bitter tasting compounds, respectively. Here we report a Ca(2+) imaging method that allows association of ligand-mediated responses to a single GRN. We find that different sweet neurons exhibit distinct response profiles when stimulated with various sugars, and likewise, different bitter neurons exhibit distinct response profiles when stimulated with a set of bitter chemicals. These observations suggest that individual neurons within a taste modality are represented by distinct repertoires of sweet and bitter taste receptors, respectively. Furthermore, we employed this novel method to identify glucose as the primary ligand for the sugar receptor Gr61a, which is not only expressed in sweet sensing neurons of classical chemosensory sensilla, but also in two supersensitive neurons of atypical taste sensilla. Thus, single cell Ca(2+) imaging can be employed as a powerful tool to identify ligands for orphan Gr proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.