ArticlePloS one2013
canEvolve: a web portal for integrative oncogenomics.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Data Visualization Support for Interdisciplinary Team Treatment Planning in Clinical Oncology: Scoping Review.Journal of medical Internet research · 2025Article
- Targeting Siglec-sialic acid checkpoint to reverse immune dysfunction mediated by plasmacytoid dendritic cells in myeloma.Blood advances · 2025Article
- Prostate cancer in omics era.Cancer cell international · 2022Article
- The Cancer Research Database (CRDB): Integrated Platform to Gain Statistical Insight Into the Correlation Between Cancer and COVID-19.JMIR cancer · 2022Article
- Aberrantly hypermethylated ARID1B is a novel biomarker and potential therapeutic target of colon adenocarcinoma.Frontiers in genetics · 2022Article
- MicroRNA Targeting.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Progressing Towards a Human-Centric Approach in Cancer Research.Frontiers in oncology · 2022Review
- Organotypic Models in Drug Development "Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development".Handbook of experimental pharmacology · 2021Article
- Updates on "Cancer Genomics and Epigenomics".World journal of clinical oncology · 2020Review
- Systems Biology and Experimental Model Systems of Cancer.Journal of personalized medicine · 2020Review
- A survey and evaluation of Web-based tools/databases for variant analysis of TCGA data.Briefings in bioinformatics · 2019Review
- MiPanda: A Resource for Analyzing and Visualizing Next-Generation Sequencing Transcriptomics Data.Neoplasia (New York, N.Y.) · 2018Article
- Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer.PloS one · 2018Article
- B-CAN: a resource sharing platform to improve the operation, visualization and integrated analysis of TCGA breast cancer data.Oncotarget · 2017Article
- Exploring and visualizing multidimensional data in translational research platforms.Briefings in bioinformatics · 2017Article
- Mining Cancer Transcriptomes: Bioinformatic Tools and the Remaining Challenges.Molecular diagnosis & therapy · 2017Review
- TRIM28 multi-domain protein regulates cancer stem cell population in breast tumor development.Oncotarget · 2017Article
- Web-based tools for microRNAs involved in human cancer.Oncology letters · 2016Article
- TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data.Nucleic acids research · 2016Article
- Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach.International journal of molecular sciences · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND &
objectiveGenome-wide profiles of tumors obtained using functional genomics platforms are being deposited to the public repositories at an astronomical scale, as a result of focused efforts by individual laboratories and large projects such as the Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium. Consequently, there is an urgent need for reliable tools that integrate and interpret these data in light of current knowledge and disseminate results to biomedical researchers in a user-friendly manner. We have built the canEvolve web portal to meet this need.
resultscanEvolve query functionalities are designed to fulfill most frequent analysis needs of cancer researchers with a view to generate novel hypotheses. canEvolve stores gene, microRNA (miRNA) and protein expression profiles, copy number alterations for multiple cancer types, and protein-protein interaction information. canEvolve allows querying of results of primary analysis, integrative analysis and network analysis of oncogenomics data. The querying for primary analysis includes differential gene and miRNA expression as well as changes in gene copy number measured with SNP microarrays. canEvolve provides results of integrative analysis of gene expression profiles with copy number alterations and with miRNA profiles as well as generalized integrative analysis using gene set enrichment analysis. The network analysis capability includes storage and visualization of gene co-expression, inferred gene regulatory networks and protein-protein interaction information. Finally, canEvolve provides correlations between gene expression and clinical outcomes in terms of univariate survival analysis.
conclusionAt present canEvolve provides different types of information extracted from 90 cancer genomics studies comprising of more than 10,000 patients. The presence of multiple data types, novel integrative analysis for identifying regulators of oncogenesis, network analysis and ability to query gene lists/pathways are distinctive features of canEvolve. canEvolve will facilitate integrative and meta-analysis of oncogenomics datasets. AVAILABILITY: The canEvolve web portal is available at http://www.canevolve.org/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.