ArticlePloS one2013
Shotgun proteomic analysis of plasma from dairy cattle suffering from footrot: characterization of potential disease-associated factors.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Serum Metabolomics and Ionomics Analysis of Hoof-Deformed Cows Based on LC-MS/MS and ICP-OES/MS.Animals : an open access journal from MDPI · 2023Article
- Characterization of variations within the rumen metaproteome of Holstein dairy cattle relative to morning feed offering.Scientific reports · 2020Article
- Article
- Proteomics analysis reveals heat shock proteins involved in caprine parainfluenza virus type 3 infection.BMC veterinary research · 2019Article
- Proteomic Analysis Revealed the Fruiting-Body Protein Profile of Auricularia polytricha.Current microbiology · 2017Article
- Nuclear magnetic resonance-based serum metabolic profiling of dairy cows with footrot.The Journal of veterinary medical science · 2016Article
- Characterisation of the circulating acellular proteome of healthy sheep using LC-MS/MS-based proteomics analysis of serum.Proteome science · 2016Article
- Analysis of protein expression changes of the Vero E6 cells infected with classic PEDV strain CV777 by using quantitative proteomic technique.Journal of virological methods · 2015Article
- Preparation of monoclonal antibodies against bovine haptoglobin.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2014Article
- Proteomic analysis of membrane proteins of vero cells: exploration of potential proteins responsible for virus entry.DNA and cell biology · 2014Article
- A polyclonal antibody against recombinant bovine haptoglobin expressed in Escherichia coli.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2013Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasma proteome of healthy dairy cattle and those with footrot was investigated using a shotgun LC-MS/MS approach. In total, 648 proteins were identified in healthy plasma samples, of which 234 were non-redundant proteins and 123 were high-confidence proteins; 712 proteins were identified from footrot plasma samples, of which 272 were non-redundant proteins and 138 were high-confidence proteins. The high-confidence proteins showed significant differences between healthy and footrot plasma samples in molecular weight, isoelectric points and the Gene Ontology categories. 22 proteins were found that may differentiate between the two sets of plasma proteins, of which 16 potential differential expression (PDE) proteins from footrot plasma involved in immunoglobulins, innate immune recognition molecules, acute phase proteins, regulatory proteins, and cell adhesion and cytoskeletal proteins; 6 PDE proteins from healthy plasma involved in regulatory proteins, cytoskeletal proteins and coagulation factors. Of these PDE proteins, haptoglobin, SERPINA10 protein, afamin precursor, haptoglobin precursor, apolipoprotein D, predicted peptidoglycan recognition protein L (PGRP-L) and keratan sulfate proteoglycan (KS-PG) were suggested to be potential footrot-associated factors. The PDE proteins PGRP-L and KS-PG were highlighted as potential biomarkers of footrot in cattle. The resulting protein lists and potential differentially expressed proteins may provide valuable information to increase understanding of plasma protein profiles in cattle and to assist studies of footrot-associated factors.
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