ArticlePloS one2013
The orthologue of the fruitfly sex behaviour gene fruitless in the mosquito Aedes aegypti: evolution of genomic organisation and alternative splicing.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 61 citations in OpenAlex.
- Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil.Insect molecular biology · 2026Article
- Mosquito sex separation using complementation of selectable traits and engineered neo-sex chromosomes.Nature communications · 2025Article
- Mosquito sex determination: recent advances and applications.Current opinion in insect science · 2025Review
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- Hybridization between Aedes aegypti and Aedes mascarensis mosquitoes leads to disruption of male sex determination.Communications biology · 2024Article
- The role ofScience advances · 2024Article
- Analysis of the Genetic Variation of theInsects · 2022Article
- Article
- Effects of Functional Depletion ofInsects · 2021Article
- femaleless Controls Sex Determination and Dosage Compensation Pathways in Females of Anopheles Mosquitoes.Current biology : CB · 2021Article
- Article
- The transformer-2 and fruitless characterisation with developmental expression profiles of sex-determining genes in Bactrocera dorsalis and B. correcta.Scientific reports · 2020Article
- Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade.PLoS genetics · 2020Article
- The fight to understand fighting: neurogenetic approaches to the study of aggression in insects.Current opinion in insect science · 2019Review
- Identification of sex determination genes and their evolution in Phlebotominae sand flies (Diptera, Nematocera).BMC genomics · 2019Article
- Two of the three Transformer-2 genes are required for ovarian development in Aedes albopictus.Insect biochemistry and molecular biology · 2019Article
- Sex determination and Aedes population control.Parasites & vectors · 2018Review
- The Nix locus on the male-specific homologue of chromosome 1 in Aedes albopictus is a strong candidate for a male-determining factor.Parasites & vectors · 2018Article
- Identification of Aedes aegypti cis-regulatory elements that promote gene expression in olfactory receptor neurons of distantly related dipteran insects.Parasites & vectors · 2018Article
- Alternative patterns of sex chromosome differentiation in Aedes aegypti (L).BMC genomics · 2017Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster the doublesex (dsx) and fruitless (fru) regulatory genes act at the bottom of the somatic sex determination pathway. Both are regulated via alternative splicing by an upstream female-specific TRA/TRA-2 complex, recognizing a common cis element. dsx controls somatic sexual differentiation of non-neural as well as of neural tissues. fru, on the other hand, expresses male-specific functions only in neural system where it is required to built the neural circuits underlying proper courtship behaviour. In the mosquito Aedes aegypti sex determination is different from Drosophila. The key male determiner M, which is located on one of a pair of homomorphic sex chromosomes, controls sex-specific splicing of the mosquito dsx orthologue. In this study we report the genomic organization and expression of the fru homologue in Ae. aegypti (Aeafru). We found that it is sex-specifically spliced suggesting that it is also under the control of the sex determination pathway. Comparative analyses between the Aeafru and Anopheles gambiae fru (Angfru) genomic loci revealed partial conservation of exon organization and extensive divergence of intron lengths. We find that Aeadsx and Aeafru share novel cis splicing regulatory elements conserved in the alternatively spliced regions. We propose that in Aedes aegypti sex-specific splicing of dsx and fru is most likely under the control of splicing regulatory factors which are different from TRA and TRA-2 found in other dipteran insects and discuss the potential use of fru and dsx for developing new genetic strategies in vector control.
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