Evidence map›Paper›PMID 23418159›Full record

ArticleNMR in biomedicine2013

Global gray and white matter metabolic changes after simian immunodeficiency virus infection in CD8-depleted rhesus macaques: proton MRS imaging at 3 T.

William E Wu, Assaf Tal, Ivan I Kirov, Henry Rusinek, Daniel Charytonowicz, James S Babb, Eva-Maria Ratai, R Gilberto Gonzalez, Oded Gonen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

William E WuDepartment of Radiology, New York University School of Medicine, New York, NY, 10016, USA.
Assaf Tal
Ivan I Kirov
Henry Rusinek
Daniel Charytonowicz
James S Babb
Eva-Maria Ratai
R Gilberto Gonzalez
Oded Gonen

Funding

PSYCHOSOCIAL COREP30AG008051 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WISNIEWSKI, THOMAS M · 1990 to 2019
$36.1M
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
MONOCYTE TRAFFIC AND THE NEUROPATHOGENESIS OF AIDSR01NS040237 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Robert Blair, Woong-Ki Kim · 1999 to 2026
$11.4M
HIGHER SPEED, FIELD &SPATIAL RESOLUTION BRAIN 3D 1H MRSR01EB001015 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GONEN, ODED · 2002 to 2011
$5.8M
MR Spectroscopy of SIV Brain InjuryR01NS050041 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GONZALEZ, RAMON GILBERTO · 2005 to 2009
$3.4M
Serial Brain 3D 1H MR Spectroscopy in Multiple SclerosisR01NS050520 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GONEN, ODED · 2005 to 2009
$2.9M
MR Spectroscopy of the Brain during Acute HIV infectionK25NS051129 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LENTZ, MARGARET R · 2005 to 2009
$745k
Serial Brain 3D 1H MR Spectroscopy in Multiple Sclerosis.R56NS050520 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GONEN, ODED · 2011 to 2011
$586k
MRS OF NEUROPROTECTION IN AN SIV MODEL OF NEUROAIDSR21NS059331 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI RATAI, EVA-MARIA · 2007 to 2008
$473k
NCRR NIH HHS P41 RR014075NCRR NIH HHS P41RR14075NIA NIH HHS P30 AG008051NIBIB NIH HHS EB01015NIBIB NIH HHS R01 EB001015NINDS NIH HHS K25 NS051129NINDS NIH HHS NS040237NINDS NIH HHS NS050041NINDS NIH HHS NS050520NINDS NIH HHS NS051129NINDS NIH HHS NS059331NINDS NIH HHS R01 NS040237NINDS NIH HHS R01 NS050041NINDS NIH HHS R01 NS050520NINDS NIH HHS R21 NS059331NINDS NIH HHS R56 NS050520
6 · The paper itself

Abstract

To test the hypotheses that global decreased neuro-axonal integrity reflected by decreased N-acetylaspartate (NAA) and increased glial activation reflected by an elevation in its marker, the myo-inositol (mI), present in a CD8-depleted rhesus macaque model of HIV-associated neurocognitive disorders. To this end, we performed quantitative MRI and 16 × 16 × 4 multivoxel proton MRS imaging (TE/TR = 33/1400 ms) in five macaques pre- and 4-6 weeks post-simian immunodeficiency virus infection. Absolute NAA, creatine, choline (Cho), and mI concentrations, gray and white matter (GM and WM) and cerebrospinal fluid fractions were obtained. Global GM and WM concentrations were estimated from 224 voxels (at 0.125 cm(3) spatial resolution over ~35% of the brain) using linear regression. Pre- to post-infection global WM NAA declined 8%: 6.6 ± 0.4 to 6.0 ± 0.5 mM (p = 0.05); GM Cho declined 20%: 1.3 ± 0.2 to 1.0 ± 0.1 mM (p < 0.003); global mI increased 11%: 5.7 ± 0.4 to 6.5 ± 0.5 mM (p < 0.03). Global GM and WM brain volume fraction changes were statistically insignificant. These metabolic changes are consistent with global WM (axonal) injury and glial activation, and suggest a possible GM host immune response.

Indexed as

Lymphocyte DepletionProton Magnetic Resonance SpectroscopyAnimalsAspartic AcidCD8-Positive T-LymphocytesCholineCreatineFemaleGray MatterInositolMacaca mulattaMaleSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusSpin LabelsWhite MatterAspartic AcidCholineCreatineInositolN-acetylaspartateSpin Labelsanimal disease modelsbrainHIV-1Macaca mulattaMRSsimian immunodeficiency virus

Identifiers

PMID23418159
PMCPMC3784644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.