ArticleObesity (Silver Spring, Md.)2013
A metabolically healthy obese phenotype in hispanic participants in the IRAS family study.
Article in Obesity (Silver Spring, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Metabolic health and cardiovascular risk among Cameroonian adults with and without obesity.PLOS global public health · 2026Article
- Article
- The joint association of cardiometabolic health and weight on mortality in the multiethnic cohort.Ethnicity & health · 2022Article
- Association of Visceral Adipose Tissue and Insulin Resistance with Incident Metabolic Syndrome Independent of Obesity Status: The IRAS Family Study.Obesity (Silver Spring, Md.) · 2021Article
- Deciphering Biochemical and Molecular Signatures Associated with Obesity in Context of Metabolic Health.Genes · 2021Article
- Metabolically Healthy Obesity.Endocrine reviews · 2020Review
- Waist Circumference Is an Anthropometric Parameter That Identifies Women with Metabolically Unhealthy Phenotypes.Nutrients · 2018Article
- Metabolically healthy versus unhealthy obesity and risk for diabetes mellitus and cardiovascular diseases.Cardiovascular endocrinology · 2017Review
- Does Metabolically Healthy Obesity Exist?Nutrients · 2016Review
- Metabolic Health Is More Important than Obesity in the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Retrospective Study.Endocrinology and metabolism (Seoul, Korea) · 2015Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveSome obese individuals appear to be protected from developing type 2 diabetes mellitus and cardiovascular disease (CVD). This has led to characterizing body size phenotypes based on cardiometabolic risk factors specifically as obese or overweight, and as metabolically healthy (MH) or metabolically abnormal (MA) based upon blood pressure, lipids, glucose homeostasis, and inflammatory parameters. The aim of this study was to measure the prevalence of and describe fat distribution across these phenotypes in a minority population. DESIGN AND
methodsHispanic participants (N = 1054) in the IRAS Family Study were categorized into different body size phenotypes. Computed tomography (CT) abdominal scans were evaluated for measures of nonalcoholic fatty liver disease (NAFLD) and abdominal fat distribution. Statistical models adjusting for familial relationships were estimated.
resultsSeventy percent (70%) of the Hispanic cohort was overweight (32%) or obese (38%). Forty-one percent (n = 138) of overweight participants and 19% (n = 74) of obese participants met criteria for MH. Adjusted analyses showed the MH phenotype was associated with lower visceral adipose tissue (VAT) and higher liver density (indicating lower fat content) in obese participants (p = 0.0005 and p = 0.0002, respectively), and lower VAT but not liver density in overweight participants (p = 0.008 and p = 0.162, respectively) compared to their MA counterparts. Odds of NAFLD were reduced in MH obese (OR = 0.34, p = 0.0007) compared to MA obese. VAT did not differ between MH obese or overweight and normal weight groups.
conclusionsThese findings suggest that lower levels of visceral and liver fat, despite overall increased total body fat, may be a defining feature of MH obesity in Hispanic Americans.
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