ArticleAnnals of neurology2013
Chronic cerebrospinal venous insufficiency: case-control neurosonography results.
Article in Annals of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Trial
- Four-dimensional flow magnetic resonance imaging and ultrasound assessment of cerebrospinal venous flow in multiple sclerosis patients and controls.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study.The British journal of radiology · 2016Article
- Chronic Cerebrospinal Venous Insufficiency: A Failed Concept.Vascular specialist international · 2015Article
- Validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association with multiple sclerosis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Article
- Cerebrospinal Venous Outflow in Multiple Sclerosis Patients versus Fatigue and/or Depression.Interventional neurology · 2014Article
- Evaluation of hemodynamic properties of cerebral venous drainage in patients with multiple sclerosis: a case-control study.Polish journal of radiology · 2014Article
- Is there any relation between chronic cerebrospinal venous insufficiency and multiple sclerosis? - a critical review.Polish journal of radiology · 2014Review
- Article
- Chronic cerebrospinal venous insufficiency: masked multimodal imaging assessment.Multiple sclerosis (Houndmills, Basingstoke, England) · 2013Article
- Evidence against the involvement of chronic cerebrospinal venous abnormalities in multiple sclerosis. A case-control study.PloS one · 2013Article
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Authors and funding
11 authors.
Funding
Abstract
objectiveChronic cerebrospinal venous insufficiency (CCSVI) has been implicated in the pathophysiology of multiple sclerosis (MS). We sought to determine whether neurosonography (NS) provides reliable information on cerebral venous outflow patterns specific to MS.
methodsThis was a single-center, prospective case-control study of volunteer MS and non-MS participants. A neurosonologist, blind to the subjects' diagnosis, used high-resolution B-mode imaging with color and spectral Doppler to systematically investigate, capture, and record extracranial and intracranial venous drainage. These neuroimaging results were evaluated and scored by an expert blinded to subjects' information and with no interactions with the participants.
resultsAltogether, 276 subjects were studied: 206 with MS and 70 non-MS. MS patients were older than non-MS subjects (48.3±9.9 vs 44.3±11.8 years, p<0.007), with durations from first symptoms and diagnosis of 13.7±10 and 9.9±7.8 years, and Expanded Disability Status Scale of 2.6±2.0. Overall, 82 subjects (29.7%) fulfilled 1 of 5 NS criteria proposed for CCSVI; 13 (4.7%) fulfilled 2 criteria required for diagnosis, and none fulfilled >2 criteria. The distribution of subjects with 0, 1, or 2 criteria did not differ significantly across all diagnostic groupings, between MS and non-MS subjects, or within MS subgroups. CCSVI was present in 7.14% of non-MS and 3.88% of MS patients (p=0.266). No significant differences emerged between MS and non-MS subjects for extracranial or intracranial venous flow rates.
interpretationNS findings described as CCSVI are much less prevalent than initially reported, and do not distinguish MS from other subjects. Our findings do not support the hypothesis that CCSVI is causally associated with MS.
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