Evidence map›Paper›PMID 23417835›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2013

Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes.

Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Nathan P Gabrielson, Jianjun Cheng

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Recent advances in neuroepigenetic editing.Current opinion in neurobiology · 2019
    Review
  6. Article
  7. Article
  8. Chitosan-Based Nanomaterials for Drug Delivery.Molecules (Basel, Switzerland) · 2018
    Review
  9. Article
  10. Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Nano-Sized Sunflower Polycations As Effective Gene Transfer Vehicles.Small (Weinheim an der Bergstrasse, Germany) · 2016
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lichen YinDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA.
Ziyuan Song
Kyung Hoon Kim
Nan Zheng
Nathan P Gabrielson
Jianjun Cheng

Funding

Developing Clinically Applicable, Cancer-Targeting Polymeric NanoconjugatesDP2OD007246 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHENG, JIANJUN · 2010 to 2010
$2.4M
Development of Helical Polypeptides for Non-Viral Gene Delivery SystemsR21EB013379 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHENG, JIANJUN · 2011 to 2012
$415k
NIBIB NIH HHS 1R21EB013379NIBIB NIH HHS R21 EB013379NIH HHS 1DP2OD007246NIH HHS DP2 OD007246
6 · The paper itself

Abstract

Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.

Indexed as

AnimalsCell MembraneChitosanDNADrug CarriersDrug DesignHep G2 CellsHumansLuciferasesMannoseMiceNanostructuresPlasmidsPolymersTransfectionChitosanDNADrug CarriersLuciferasesMannosePolymers

Identifiers

PMID23417835
PMCPMC3757134

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.